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Table 1 (abstract P-318). Molecular characteristics of the nano-stars used in this study (sorted in ascending order of arm grafting density)

From: Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

Designation

Namea

Grafting density

(arms/nm2)

Mn Polymer/Particle

(kg/mol)

PDI

Subgroupb

P300_5

NP@(PDMAEMA300)5

0.006

235

1.2

I

P242_9

NP@(PDMAEMA242)9

0.011

342

1.2

I

P528_20

NP@(PDMAEMA528)20

0.024

1660

1.3

I

P1100-4350_98

NP@(PDMAEMA1100-b-PDEGMA4350)98

0.038

975000

1.6

n.a.

P1037_46

NP@(PDMAEMA1037)46

0.054

7498

1.6

II

P1470_54

NP@(PDMAEMA1470)54

0.064

12470

1.4

II

P312_337

NP@(PDMAEMA312)337

0.149

16513

1.4

III

P477_411

NP@(PDMAEMA477)411

0.182

30825

1.5

III

P1240_653

NP@(PDMAEMA1240)653

0.289

127335

1.5

III

P439_657

NP@(PDMAEMA439)657

0.291

45333

1.4

III

P1616_679

NP@(PDMAEMA1616)679

0.300

172466

1.3

III

  1. PDMAEMA: poly(dimethylaminoethyl methacrylate). PDEGMA: poly(diethylene glycol) methyl ether methacrylate). PDI: polydispersity index (Mw/Mn). a: NP@(PDMAEMABlock length)Arm number. b: The classification of the variants in the subgroups is based on the arm density and on the hydrodynamic radii (Rh) of the corresponding polyplexes covering a wide range of N/P-ratios and analyzed for size by DLS after a 30 min incubation (I: low arm density, 300 < Rh (nm) ≤ 1000; II: middle arm density, 50 < Rh (nm) ≤ 200; III: high arm density, 50 < Rh (nm) ≤ 300). n.a.: not available