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Table 1 Reproduced from Guidance Framework for Testing Genetically Modified Mosquitoes. World Health Organisation [11] Table 1.1 Genetically Modified Mosquito (GMM) technologies currently under development. Note that the characterization does not describe all genetic systems in development, there are additionally “threshold-dependent” gene drive systems that have an element of local population control or reversal by design [14]

From: Means and ends of effective global risk assessments for genetic pest management

  Approach  
Self- limiting Self-sustaining
Population suppression Modification reduces the number of progeny Modification reduces the number of progeny
Possesses either no gene drive or weak drive that will pass the modification through only a limited number of generations Possesses strong gene drive
Not intended to persist in the absence of continued releases Intended to spread the modification indefinitely or until the mosquito population is eliminated
Population replacement Modification limits pathogen replication, thereby reducing transmission Modification limits pathogen replication, thereby reducing transmission
Possesses weak gene drive that will pass the modification through only a limited number of generations Possesses strong gene drive
Intended to spread the modification through the population indefinitely Intended to persist only until diluted out of the population