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Table 1 Features of the probes (X, Z) and SNPs (G) analyzed at 10 genes selected due to the associations between methylation levels and ΔHDL in Zhao et al. [3]

From: Investigating potential causal relationships between SNPs, DNA methylation and HDL

Gene

CpGs: # in gene a/# nearby b (# genes nearby)

SNPs: # in Set F/# in Set R

# probes associated with ΔHDL c

Gene

CpGs: # in gene a/# nearby b (# genes nearby)

SNPs: # in Set F/# in Set R

#CpGs associated with ΔHDL c

RNMT;C18orf19

15/31(4)

128/21

1

GTF2IRD2

6/20 (4)

0/0

1

MIR130B

3/77(9)

90/10

2

VPS25 d

11/41(19)

59/3

4

C6orf141

14/34(5)

53/8

2

SBSN d

8/45 (3)

102/4

1

TUBB3

20/214 (8)

0/0

1

TPM4

29/74 (7)

161/14

1

TBX15

109/57(1)

91/63

2

PARP15

17/60(5)

146/1

4

  1. a Probes located within 20 kb of the gene of interest
  2. b Probes within 20 kb of neighboring genes, and up to (±100 kb) from the gene of interest; ie, CpGs used as potential pleiotropic phenotypes in the CIV method
  3. c Probes that showed significant associations in univariate analysis at significance level 0.01 with Bonferroni correction
  4. d Only probes within 20 kb (instead of 100 kb) of neighboring genes around genesVPS25and SBSN were used as Z