Direct and indirect genetic effects on triglycerides through omics and correlated phenotypes

BMC Proceedings

Table 1 TG-associated SNPs and nearby CpGs included in SEM models

Rsid	Chr	Pos (hg19)	Gene	EA/OA	EAF	PMID	# of CpGs ± 10 kb	CpGs included in final model^a	Parameters	# Variables (Dependent/Independent)
rs1748195	1	63,049,593	DOCK7	G/C	0.636	18193043	1	cg00161770	55	9/6
rs645040	3	135,926,622	RPL31P23/PCCB	A/C	0.807	24097068	2	cg15219878	55	9/6
rs998584	6	43,757,896	VEGFA	C/A	0.543	24097068	6	cg03143046, cg01353538, cg20940044, cg25373579, cg23879496, cg12682870	75	14/6
rs10503669	8	19,847,690	LPL	G/T	0.909	18193043	0	cg18449136^a	55	9/6
rs964184	11	116,154,127	ZPR1/ZNF259	G/C	0.874	24097068	24	cg06595719, cg14815609, cg05862431, cg11835342, cg14371153, cg17490921	75	14/6
rs4765127	12	123,026,120	ZNF664	G/T	0.672	24097068	13	cg19078769, cg00201185, cg10922530, cg02647265	67	12/6
rs4775041	15	58,674,695	Intergenic	G/C	0.720	18193043	1	cg25188724	55	9/6
rs3198697	16	15,129,940	PDXDC1	C/T	0.569	24097068	5	cg16724811, cg06978461, cg03245889, cg03928410, cg26985681	71	13/6
rs1121980	16	53,809,247	FTO	C/T	0.529	24097068	2	cg02252501, cg03312170	59	10/6
rs8077889	17	41,878,166	C17orf105/MPP3	T/G	0.798	24097068	2	cg13317831, cg01571583	59	10/6
rs7248104	19	7,224,431	INSR	G/A	0.575	24097068	2	cg09779027, cg00428638	59	10/6
rs10401969	19	19,407,718	SUGP1	A/G	0.929	24097068	5	cg00477287, cg01313994, cg01559787, cg08112740, cg19643441	71	13/6

Abbreviations: Chr chromosome, EA effect allele, OA other allele, PMID pubmed article ID number, Pos base pair position on chromosome
^aCpGs within 10 kb ± and included in the final model are listed for all SNPs except rs10503669, which had only one CpG < 20 kb ±

ISSN: 1753-6561