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Table 2 Parameter estimates for significant pathways from SNP, through intermediate exposure, to TG4

From: Direct and indirect genetic effects on triglycerides through omics and correlated phenotypes

Intermediate

Pathways

Beta

SE

P

RMSEA

CFI

TLI

rs645040

 Through HDL3

SNP → HDL3 → HDL4 → TG4

0.229

0.115

0.046

0.083

0.96

0.93

SNP → HDL3 → TG3 → TG4

0.597

0.286

0.037

rs964184

 Through TG1

SNP → TG1 → TG2 → TG3 → TG4

−12.48

2.406

< 0.001

0.07

0.94

0.92

 Through HDL1

SNP → HDL1 → HDL2 → TG2 → TG3 → TG4

−0.819

0.392

0.037

SNP → HDL1 → HDL2 → HDL3 → TG3 → TG4

−2.204

0.903

0.015

SNP → HDL1 → HDL2 → HDL3 → HDL4 → TG4

− 0.857

0.382

0.025

SNP → HDL1 → TG1 → TG2 → TG3 → TG4

−2.568

1.011

0.011

rs4765127

 Through cg02647265

SNP → cg02647265 → TG2 → TG3 → TG4

0.323

0.153

0.034

0.074

0.95

0.92

rs1121980

 Through HDL3

SNP → HDL3 → TG3 → TG4

−0.547

0.249

0.028

0.08

0.96

0.93

rs10401969

 Through HDL1

SNP → HDL1 → TG1 → TG2 → TG3 → TG4

2.552

1.166

0.029

0.076

0.94

0.91

SNP → HDL1 → HDL2 → HDL3 → TG3 → TG4

2.098

0.968

0.03

SNP → HDL1 → HDL2 → HDL3 → HDL4 → TG4

0.801

0.407

0.049

  1. We highlight all significant pathways with a focus only on significant SNP effects (P value < 0.05 and directionally consistent). Bonferroni significant pathways (P value < 0.004) are bolded