Skip to main content

Table 2 Proportion of times test statistic, GSC, was rejected (p < 0.05) across 200 simulations, by choice of test statistic and by type of gene

From: Evaluating the performance of gene-based tests of genetic association when testing for association between methylation and change in triglyceride levels at GAW20

Statistic Contains major causal variants Contains minor causal variants Contains no causal variants
Sum ln p 0.367 0.07 0.04
Sum −(lnp)2 0.398 0.06 0.04
Min p 0.431 0.03 0.02
pT 0.10 0.460 0.04 0.03
pT 0.05 0.469 0.04 0.03
pT 0.01 0.467 0.03 0.02
Single markera 0.403 0.03 0.02
  1. aSingle marker test used a Bonferroni-corrected significance threshold of \( \frac{0.05}{m_k} \)