Evaluating the performance of gene-based tests of genetic association when testing for association between methylation and change in triglyceride levels at GAW20

Table 2 Proportion of times test statistic, G_SC, was rejected (p < 0.05) across 200 simulations, by choice of test statistic and by type of gene

Statistic	Contains major causal variants	Contains minor causal variants	Contains no causal variants
Sum ln p	0.367	0.07	0.04
Sum −(lnp)²	0.398	0.06	0.04
Min p	0.431	0.03	0.02
pT 0.10	0.460	0.04	0.03
pT 0.05	0.469	0.04	0.03
pT 0.01	0.467	0.03	0.02
Single marker^a	0.403	0.03	0.02

^aSingle marker test used a Bonferroni-corrected significance threshold of \( \frac{0.05}{m_k} \)

ISSN: 1753-6561