Evaluating the performance of gene-based tests of genetic association when testing for association between methylation and change in triglyceride levels at GAW20

Table 3 erformance across major-effect genes

Gene	SNP heritability	No. SNP-CpG pairs	MAF of causal variant	Sum lnp	Sum −ln²p	Minp	pT 0.10	pT 0.05	pT 0.01	Single marker
SIPA1L2^a	.125	141	0.11	0.35	0.42	0.73	0.58	0.65	0.72	0.69
SYNTH1^b	.100	23	0.19	0.79	0.74	0.48	0.65	0.61	0.52	0.41
LYRM4	.075	63	0.10	0.17	0.18	0.22	0.23	0.22	0.25	0.21
HS3ST3A1	.050	29	0.41	0.24	0.22	0.21	0.24	0.24	0.21	0.19
MSRB2^a	.025	32	0.14	0.72	0.72	0.41	0.65	0.59	0.48	0.39

ISSN: 1753-6561