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Table 3 erformance across major-effect genes

From: Evaluating the performance of gene-based tests of genetic association when testing for association between methylation and change in triglyceride levels at GAW20

Gene SNP heritability No. SNP-CpG pairs MAF of causal variant Sum lnp Sum −ln2p Minp pT 0.10 pT 0.05 pT 0.01 Single marker
SIPA1L2a .125 141 0.11 0.35 0.42 0.73 0.58 0.65 0.72 0.69
SYNTH1b .100 23 0.19 0.79 0.74 0.48 0.65 0.61 0.52 0.41
LYRM4 .075 63 0.10 0.17 0.18 0.22 0.23 0.22 0.25 0.21
HS3ST3A1 .050 29 0.41 0.24 0.22 0.21 0.24 0.24 0.21 0.19
MSRB2a .025 32 0.14 0.72 0.72 0.41 0.65 0.59 0.48 0.39
  1. aNearest gene within 50,000 bp of major-effect SNP
  2. bArtificial “gene” containing all SNPs within 50,000 bp of major effect SNP