Evaluating the performance of gene-based tests of genetic association when testing for association between methylation and change in triglyceride levels at GAW20

Table 4 Performance across sets of SNP-CpG variant pairs containing major-effect variants

Gene	Total SNP heritability	No. SNP-CpG pairs	Sum lnp	Sum-ln²p	Minp	pT 0.10	pT 0.05	pT 0.01	Single marker
CAUSAL5	0.375	5	1.00	1.00	1.00	1.00	1.00	1.00	1.00
UNION5	0.375	288	0.73	0.86	0.74	0.93	0.92	0.89	0.70
UNION2	0.125	92	0.23	0.26	0.26	0.25	0.26	0.27	0.23
NOISE5	0.375	288	0.06	0.11	0.64	0.50	0.61	0.70	0.64
NOISE2	0.125	92	0.03	0.09	0.20	0.14	0.15	0.18	0.20

ISSN: 1753-6561