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Table 2 Result of pathway analysis for the red, green, and brown modules

From: Network analysis of drug effect on triglyceride-associated DNA methylation

Pathway

# DE

p Value

Red module

 Sphingolipid signaling pathway

5

1.81 × 10−32

 Glycerophospholipid metabolism

4

0.00016

 Phospholipase D signaling pathway

4

0.0008

 Cyclic adenosine monophosphate signaling pathway

4

0.00149

 Choline metabolism in cancer

3

0.00561

 Ether lipid metabolism

2

0.01523

 Glycerolipid metabolism

2

0.03437

Green module

 Metabolic pathway

6

0.00471

 Epstein-Barr virus infection

3

0.1168

 Notch signaling pathway

2

0.1168

 Pyrimidine metabolism

2

0.1492

 Basal cell carcinoma

2

0.1492

Brown module

 Proteoglycans in cancer

6

0.00208

Salmonella infection

4

0.00208

 Terpenoid backbone biosynthesis

3

0.00208

 Pathways in cancer

7

0.00239

 Gonadotropin-releasing hormone signaling pathway

4

0.00239

  1. Pathway indicates the KEGG pathway being tested; # DE is the number of genes that are differentially expressed in our module; and the false discovery rate is the p value for overrepresentation