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Table 1 Estimates of regression coefficients for methylation, fenofibrate, and methylation-fenofibrate interactions, with and without adjusting for HDL using the whole samplea

From: Assessment of fenofibrate-methylation interactions on triglycerides using longitudinal family data

   

With adjustment for HDL

Without adjustment for HDL

Chr

Gene

CpG

Methylation (p)

Treatment (p)

Interaction (p)

Methylation (p)

Treatment (p)

Interaction (p)

1

ZNF692

cg02899039

−0.16 (0.21)

−0.48 (1.11 × 10 −60 )

1.13 (8.14 × 10 −8 )

0.24 (9.22 × 10− 2)

−0.35 (1.25 × 10− 38)

0.35 (2.27 × 10− 2)

1

HS2ST1

cg07212563

0.56 (0.13)

0.83 (0.13)

−1.36 (4.34 × 10−2)

0.72 (4.24 × 10− 2)

2.28 (2.80×10 − 7 )

−2.84 (3.91 × 10 − 9 )

1

ZNF692

cg11817309

− 0.02 (0.45)

− 0.44 (1.90 × 10 −71 )

1.24 (1.24 × 10 − 14 )

0.51 (2.03 × 10− 5)

−0.34 (1.38 × 10− 47)

0.35 (2.00 × 10− 2)

3

SPSB4

cg20354777

0.48 (0.09)

1.77 (7.07 × 10 −7 )

− 2.68 (1.58 × 10 − 9 )

0.62 (1.94 × 10− 2)

1.56 (6.09 × 10 − 7 )

− 2.32 (2.38 × 10 − 9 )

5

SDHA

cg00089430

1.49 (0.02)

2.92 (3.42 × 10 − 6 )

− 3.81 (1.22 × 10 − 7 )

1.07(3.52  × 10− 2)

2.20 (4.26 × 10− 4)

− 2.89 (6.20 × 10− 5)

8

PBK

cg17795291

0.28 (0.17)

0.34 (0.34)

−0.85 (0.17)

0.45 (3.63 × 10− 2)

3.25 (5.91 × 10 − 7 )

−3.99 (3.70 × 10 − 8 )

9

BRD3

cg13773148

1.42 (6.49 × 10−3)

3.79 (9.84 × 10− 4)

−4.60 (2.88 × 10− 4)

1.40 (4.00 × 10− 3)

5.19 (4.00 × 10 − 7 )

− 6.04 (7.05 × 10 − 8 )

13

MIPEP

cg14710025

−1.64 × 10− 2 (0.48)

0.89 (0.14)

− 1.48 (5.91 × 10− 2)

0.36 (12.74 × 10− 2)

2.54 (2.65 × 10 − 6 )

− 3.26 (1.28 × 10 − 7 )

16

C16orf13

cg16757281

−3.24 (5.66 × 10 −5 )

−0.79 (7.07 × 10 − 26 )

6.75 (4.96 × 10 − 9 )

− 2.90 (7.98 × 10− 5)

−0.63 (2.59 × 10− 14)

5.20 (1.11 × 10− 5)

19

TNFSF14

cg23071186

−0.93 (7.90 × 10 −5 )

− 0.76 (3.87 × 10 − 27 )

1.42 (5.53 × 10 − 8 )

−0.79 (2.18 × 10− 4)

−0.600 (1.75 × 10− 22)

1.09 (1.12 × 10− 6)

21

ABCC13

cg04985582

−0.35 (3.28 × 10−3)

− 0.75 (< 10− 20)

0.57 (2.80 × 10− 6)

− 0.31 (2.20 × 10− 3)

−0.69 (< 10 − 20 )

0.61 (3.90 × 10 − 9 )

  1. aTable shows only CpGs with a p value for the interaction ≤1.43 × 10− 7 on log-transformed TG, adjusted for age, sex, study site, and smoking. The numbers in boldface refers to estimates and p values for the main and interaction effects where significant methylation-fenofibrate interactions were observed. A total of 421 individuals from 138 families with both pre- and posttreatment data were included in these analyses