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Table 2 Summary of 18 genes with previous evidence of association with triglyceride levels

From: Epigenome wide association study of SNP–CpG interactions on changes in triglyceride levels after pharmaceutical intervention: a GAW20 analysis

Gene

Chr

# of significant interactionsa (total)

Smallest interaction p value

SNP pvalueb

SNP location (bp)

Interaction (rs#:cg#)c

APOA1

11

1 (16)

0.0316

0.296

116,707,207

rs563838:cg24984312

APOA5

11

1 (12)

0.0316

0.296

116,707,207

rs563838:cg24984312

APOB

2

0 (13)

0.0511

0.124

21,318,003

rs312042:cg23349726

APOC3

11

1 (17)

0.0316

0.296

116,707,207

rs563838:cg24984312

BUD13

11

0 (13)

0.0866

0.904

116,570,686

rs1784042:cg19442415

CETP

16

1 (19)

0.0184

0.502

56,971,665

rs17241126:cg05062620

CLIP2

7

0 (2)

0.656

0.662

73,771,865

rs2718277:cg07814763

DOCK7

1

3 (75)

0.0261

0.341

63,034,240

rs12122434:cg00161770

FADS1

11

1 (16)

0.00430

0.740

61,581,397

rs444803:cg11606466

FADS2

11

1 (26)

0.00430

0.740

61,581,397

rs444803:cg11606466

FADS3

11

1 (20)

0.00351

0.830

61,710,585

rs1675102:cg16084190

GALNT2

1

2 (123)

0.0409

0.605

230,224,139

rs11588595:cg11424376

GCKR

2

1 (7)

0.0435

0.0846

27,730,170

rs17706100:cg22903471

LPL

8

1 (24)

0.0463

0.497

19,794,163

rs17091651:cg04035597

MLXIPL

7

0 (11)

0.106

0.373

73,083,725

rs884843:cg12958963

OTOR

20

1 (46)

0.0290

0.469

16,748,375

rs1883698:cg07500957

PLTP

20

2 (35)

0.0251

0.983

44,576,565

rs3795126:cg17262492

TRIB1

8

0 (8)

0.135

0.638

126,445,881

rs13255114:cg22644321

  1. aWith a significance level of 0.05
  2. bFrom a model with only main effects terms for CpG and SNP (ie, Eq. 1 without the interaction term)
  3. cDuplicates are a result of the overlapping nature of several of the genes