Fig. 1 (abstract P-447).

Simulation of shear distribution at manufacturing scale (A), shear level at small-scale model for different nozzle diameters (F). Impact of high shear simulation at manufacturing scale (B to D) small-scale (G to I) and on cell density, viability and cell diameter. Recovery of cell viability in production bioreactor at small scale (E) and manufacturing scale (J). In all the graphs, darker shades indicate highest shear stress, and among manufacturing runs, black run indicates the run before remediation of the manufacturing skid, colored runs are post-remediation, grey are small-scale reference for comparison