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Table 1 (abstract A5). Study characteristics

From: Novelties in Sport Sciences

Study N Study design Supplementation protocols Outcome
Ostojic et al. [1] 48 RCT GAA (1.2 a, 2.4 b, or 4.8 c gr/d) or placebo d for 6 weeks Handgrip strength ↑ a, b, c
1 RM Bench press ↑ a, b, c
Vertical jump ↔ a, b, c, d
Anaerobic power ↔ a, b, c, d
Aerobic capacity ↔ a, b, c, d
Semeredi et al. [2] 14 RCCT 1 gr of GAA and 3 gr of creatine/d a or
4 gr/d of creatine for 4 weeks b
Total creatine ↑ a, b
Brain creatine ↑ a, b
1RM Bench press ↑ a, b
tHcy (μmol/L) ↔ a
VO2max ↔ a, b
Ostojic et al. [3] 24 RCT GAA (2.4 gr/d) a or placebo b by oral administration for 6 weeks Serum GAA ↑ a
Serum creatine ↑ a
Serum creatinine ↑ a
Serum tHcy ↑ a
Serum AST↔ a, b
Ostojic et al. [4] 24 RCT 2·4 gr GAA/d a, or 2·4 gr/d of GAA with 1·6 gr/d of betaine hydrochloride, 5 mg/d of vitamin B12, 10 mg/d of vitamin B6, and 600 mg/d of folic acid b Serum creatine ↑ a, b
Serum tHcy ↑ a, ↔ b
Ostojic et al. [5] 48 RCT GAA (1.2 a, 2.4 b, or 4.8 c gr/d) or placebo (Inulin) d for 6 weeks Serum GAA a, b, c
Serum creatine a, b, c
Serum creatinine a, b, c
Vitamin B6, B12 a, b, c, d
tHcy (μmol/L) a, b, d; ↑ c
Ostojic et al. [6] n=10 UINT 2 gr of GAA and 2 gr of creatine/d for 4 weeks tHcy (μmol/L)
  1. Legend: N – participants, RCT- Randomized, double-blind control trail, RCCT- Randomized, double-blind crossover trail, UINT - Uncontrolled interventional trial, GAA - Guanidinoacetic acid, tHcy- total homocysteine; ↑- increased; ↔ no change; gr/d- grams per day; Asterix a, b, c, d - represents different study groups