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  1. DNA methylation plays an important role in normal human development and disease. In epigenome-wide association studies (EWAS), a univariate test for association between a phenotype and each cytosine-phosphate-...

    Authors: Chong Wu, Jun Young Park, Weihua Guan and Wei Pan
    Citation: BMC Proceedings 2018 12(Suppl 9):60
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  2. The Genetic Analysis Workshop (GAW) presents an opportunity to collaboratively evaluate methodology relevant to current issues in genetic epidemiology. The GAW20 data combine real clinical trial data with fict...

    Authors: Elizabeth R. Piette and Jason H. Moore
    Citation: BMC Proceedings 2018 12(Suppl 9):59
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  3. In the search for an understanding of how genetic variation contributes to the heritability of common human disease, the potential role of epigenetic factors, such as methylation, is being explored with increa...

    Authors: Jenna Veenstra, Anya Kalsbeek, Karissa Koster, Nathan Ryder, Abbey Bos, Jordan Huisman, Lucas VanderBerg, Jason VanderWoude and Nathan L. Tintle
    Citation: BMC Proceedings 2018 12(Suppl 9):58
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  4. There has been significant interest in investigating genome-wide and epigenome-wide associations with lipids. Testing at the gene or region level may improve power in such studies.

    Authors: Razvan G. Romanescu, Osvaldo Espin-Garcia, Jin Ma and Shelley B. Bull
    Citation: BMC Proceedings 2018 12(Suppl 9):57
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  5. Genome-wide association studies often collect multiple phenotypes for complex diseases. Multivariate joint analyses have higher power to detect genetic variants compared with the marginal analysis of each phen...

    Authors: Xuan Deng, Biqi Wang, Virginia Fisher, Gina Peloso, Adrienne Cupples and Ching-Ti Liu
    Citation: BMC Proceedings 2018 12(Suppl 9):55
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  6. We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-feno...

    Authors: Juan M. Peralta, Nicholas B. Blackburn, Arthur Porto, John Blangero and Jac Charlesworth
    Citation: BMC Proceedings 2018 12(Suppl 9):52
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  7. Genome-wide association studies have helped us identify a wealth of genetic variants associated with complex human phenotypes. Because most variants explain a small portion of the total phenotypic variation, h...

    Authors: Arthur Porto, Juan M. Peralta, Nicholas B. Blackburn and John Blangero
    Citation: BMC Proceedings 2018 12(Suppl 9):51
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  8. Although methylation data continues to rise in popularity, much is still unknown about how to best analyze methylation data in genome-wide analysis contexts. Given continuing interest in gene-based tests for n...

    Authors: Jason Vander Woude, Jordan Huisman, Lucas Vander Berg, Jenna Veenstra, Abbey Bos, Anya Kalsbeek, Karissa Koster, Nathan Ryder and Nathan L. Tintle
    Citation: BMC Proceedings 2018 12(Suppl 9):50
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  9. In GAW20, we investigated the association of specific genetic regions of interest (ROIs) with log-transformed triglyceride (TG) levels following lipid-lowering medication using epigenetic and genetic markers. ...

    Authors: Summaira Yasmeen, Patricia Burger, Stefanie Friedrichs, Sergi Papiol and Heike Bickebƶller
    Citation: BMC Proceedings 2018 12(Suppl 9):47
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  10. In this paper, a fully statistical investigation of the control of family structure as random effects is analyzed and discussed, using both the genome-wide association studies (GWAS) data and simulated data. T...

    Authors: Yayun Hsu, Jonathan Auerbach, Tian Zheng and Shaw-hwa Lo
    Citation: BMC Proceedings 2018 12(Suppl 9):42
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  11. In this paper, we consider the use of the least absolute shrinkage and selection operator (LASSO)-type regression techniques to detect important genetic or epigenetic loci in genome-wide association studies (G...

    Authors: Wenda Zhou and Shaw-Hwa Lo
    Citation: BMC Proceedings 2018 12(Suppl 9):40
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  12. Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses of longitudinal data on the phenotypes may lead...

    Authors: Hemant Kulkarni, Indranil Mukhopadhyay and Saurabh Ghosh
    Citation: BMC Proceedings 2018 12(Suppl 9):39
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  13. DNA methylation levels at cytosine-phosphate-guanine (CpG) sites with multimodal distributions among different samples have been reported recently. One possible explanation for such variability is that genetic...

    Authors: Ke Hu and Jing Li
    Citation: BMC Proceedings 2018 12(Suppl 9):36
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  14. A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure. Using these models, we estimate genome-wide...

    Authors: Haakon E. Nustad, Christian M. Page, Andrew H. Reiner, Manuela Zucknick and Marissa LeBlanc
    Citation: BMC Proceedings 2018 12(Suppl 9):31
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  15. High-throughput platforms allow the characterization of thousands of previously known methylation sites. These platforms have great potential for investigating the epigenetic effects that are partially respons...

    Authors: Marcio Almeida, Juan Peralta, Jose Garcia, Vincent Diego, Harald Goring, Sarah Williams-Blangero and John Blangero
    Citation: BMC Proceedings 2018 12(Suppl 9):29
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  16. Epigenome-wide association studies (EWAS) have traditionally focused on the association test of single epigenetic markers with complex traits. However, it is possible that multiple cytosine-phosphate-guanine (...

    Authors: Biqi Wang, Anita L. DeStefano and Honghuang Lin
    Citation: BMC Proceedings 2018 12(Suppl 9):28
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  17. GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical inter...

    Authors: Nathan L. Tintle, David W. Fardo, Mariza de Andrade, Stella Aslibekyan, Julia N. Bailey, Justo Lorenzo Bermejo, Rita M. Cantor, Saurabh Ghosh, Philip Melton, Xuexia Wang, Jean W. MacCluer and Laura Almasy
    Citation: BMC Proceedings 2018 12(Suppl 9):26
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  18. The GAW20 simulation data set is based upon the companion Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study fenofibrate clinical trial data set that forms the real data example for GAW20. The sim...

    Authors: Aldi T. Kraja, Ping An, Petra Lenzini, Shiou J. Lin, Christine Williams, James E. Hicks, E. Warwick Daw and Michael A. Province
    Citation: BMC Proceedings 2018 12(Suppl 9):25
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  19. Mixed models are a useful tool for evaluating the association between an outcome variable and genetic variables from a family-based genetic study, taking into account the kinship coefficients. When there are u...

    Authors: Subha Datta, Yixin Fang and Ji Meng Loh
    Citation: BMC Proceedings 2018 12(Suppl 9):24
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  20. DNA methylation is an epigenetic mechanism that has been proposed as a possible link between genetic and environmental determinants of disease. Prior studies reported robust associations between the methylatio...

    Authors: Sergi Sayols-Baixeras, Hemant K. Tiwari and Stella W. Aslibekyan
    Citation: BMC Proceedings 2018 12(Suppl 9):23
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  21. Even though there has been great success in identifying lipid-associated single-nucleotide polymorphisms (SNPs), the mechanisms through which the SNPs act on each trait are poorly understood. The emergence of ...

    Authors: Anne E. Justice, Annie Green Howard, Lindsay FernƔndez-Rhodes, Misa Graff, Ran Tao and Kari E. North
    Citation: BMC Proceedings 2018 12(Suppl 9):22
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  22. Using data on 680 patients from the GAW20 real data set, we conducted Mendelian randomization (MR) studies to explore the causal relationships between methylation levels at selected probes (cytosine-phosphate-...

    Authors: Lai Jiang, Kaiqiong Zhao, Kathleen Klein, Angelo J. Canty, Karim Oualkacha and Celia M. T. Greenwood
    Citation: BMC Proceedings 2018 12(Suppl 9):20
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  23. Dissemination of research results is a key component of the research continuum and is commonly achieved through publication in peer-reviewed academic journals. However, issues of poor quality reporting in the ...

    Authors: Jacqueline Galica, Alyssandra Chee-a-tow, Shikha Gupta, Atul Jaiswal, Andrea Monsour, Andrea C. Tricco, Kelly D. Cobey and Nancy J. Butcher
    Citation: BMC Proceedings 2018 12(Suppl 10):18
    Content type: Meeting Report Published on:

    This article is part of a Supplement: Volume 12 Supplement 10

  24. The use of digital technologies to improve access to health is gaining momentum in Africa. This is more pertinent with the increasing penetration of mobile phone technology and internet use, and calls for inno...

    Authors: Candide Tran Ngoc, Noella Bigirimana, Derrick Muneene, Juliet Evelyn Bataringaya, Prebo Barango, Hani Eskandar, Raissah Igiribambe, Ayomide Sina-Odunsi, Jeanine Umutesi Condo and Olushayo Olu
    Citation: BMC Proceedings 2018 12(Suppl 11):17
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 12 Supplement 11

  25. The emergence of new technologies for genetic modification has broadened the range of possible new products. The regulations of many countries that could benefit from these new products may not be prepared to ...

    Authors: Paulo P. Andrade, MarĆ­lia Andreza da Silva Ferreira, Marta Silva Muniz and Amaro de Casto Lira-Neto
    Citation: BMC Proceedings 2018 12(Suppl 8):16
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  26. Frameworks that govern the development and application of novel products, such as the products of synthetic biology, should involve all those who are interested or potentially affected by the products. The gov...

    Authors: Andrew Stirling, K. R. Hayes and Jason Delborne
    Citation: BMC Proceedings 2018 12(Suppl 8):15
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  28. The development and use of genetic technologies is regulated by countries according to their national laws and governance structures. Legal frameworks require comprehensive technical evidence to be submitted b...

    Authors: Geoff Turner, Camilla Beech and Lucia Roda
    Citation: BMC Proceedings 2018 12(Suppl 8):13
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  29. Policy and management related to the release of organisms generated by emerging biotechnologies for pest management should be informed through public engagement. Regulatory decisions can be conceptually distin...

    Authors: Michael M. Burgess, John D. Mumford and James V. Lavery
    Citation: BMC Proceedings 2018 12(Suppl 8):12
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  30. The New Partnership for Africaā€™s Development (NEPAD) Agency recognizes that Africa is in a period of transition and that this demands exploring and harnessing safe advances made in science-based innovations in...

    Authors: Barbara Glover, Olalekan Akinbo, Moussa Savadogo, Samuel Timpo, Godwin Lemgo, Woldeyesus Sinebo, Sunday Akile, Silas Obukosia, Jeremy Ouedraogo, Margareth Ndomondo-Sigonda, Muffy Koch, Diran Makinde and Aggrey Ambali
    Citation: BMC Proceedings 2018 12(Suppl 8):11
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  31. In October 2016, a two-day meeting of 65 academic, government and industry professionals was held at North Carolina State University for early-stage discussions about the international governance of gene drives: ...

    Authors: Zachary S. Brown, Lucy Carter and Fred Gould
    Citation: BMC Proceedings 2018 12(Suppl 8):10
    Content type: Introduction Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  32. Gene drives are systems of biased inheritance that enhance the likelihood a sequence of DNA passes between generations through sexual reproduction and potentially throughout a local population and ultimately a...

    Authors: James P. Collins
    Citation: BMC Proceedings 2018 12(Suppl 8):9
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  33. Universal Health Coverage (UHC)is central to the health Sustainable Development Goals(SDG). Working towards UHC is a powerful mechanism for achieving the right to health and promoting human development which i...

    Authors: Martin Okechukwu C. Ota, Doris Gatwiri Kirigia, Emil Asamoah-Odei, Pamela Suzanne Drameh-Avognon, Olushayo Olu, Mwelecele Ntuli Malecela, Joseph Waogodo Cabore and Matshidiso Rebecca Moeti
    Citation: BMC Proceedings 2018 12(Suppl 7):8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 12 Supplement 7

  34. After publication of the original article [1], it was noticed one of the authorā€™s Given Names was misspelled. Sarah Richā€™s name was misspelled as Sara Rich. The authorā€™s name is correctly presented in the auth...

    Authors: Jill Thompson, Chi-Chi Undie, Avni Amin, Brooke Ronald Johnson, Rajat Khosla, Leopold Ouedraogo, Triphonie Nkurunziza, Sarah Rich, Elizabeth Westley, Melissa Garcia, Harriet Birungi and Ian Askew
    Citation: BMC Proceedings 2018 12:7
    Content type: Correction Published on:

    The original article was published in BMC Proceedings 2018 12:5

  35. The Office of Dietary Supplements, the National Institute on Minority Health and Health Disparities, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases, a...

    Authors: LaVerne L. Brown, Barbara Cohen, Derrick Tabor, Giovanna ZappalĆ , Padma Maruvada and Paul M. Coates
    Citation: BMC Proceedings 2018 12(Suppl 6):6
    Content type: Meeting Report Published on:

    This article is part of a Supplement: Volume 12 Supplement 6

  36. In April 2016, the Population Council, in partnership with the World Health Organization (WHO) and the International Consortium for Emergency Contraception, convened a regional meeting in Lusaka, Zambia, geare...

    Authors: Jill Thompson, Chi-Chi Undie, Avni Amin, Brooke Ronald Johnson, Rajat Khosla, Leopold Ouedraogo, Triphonie Nkurunziza, Sara Rich, Elizabeth Westley, Melissa Garcia, Harriet Birungi and Ian Askew
    Citation: BMC Proceedings 2018 12(Suppl 5):5
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 12 Supplement 5

    The Correction to this article has been published in BMC Proceedings 2018 12:7

  37. Migrants and refugees face challenges accessing both healthcare and good social determinants of health in Malaysia. Participants at the ā€œMigrant and Refugee Health in Malaysia workshop, Kuala Lumpur, 9-10 Nove...

    Authors: Nicola S. Pocock, Rapeepong Suphanchaimat, Chee Khoon Chan, Erwin Martinez Faller, Nicholas Harrigan, Veena Pillai and Kolitha Wickramage
    Citation: BMC Proceedings 2018 12(Suppl 4):4
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  40. Primary ciliary dyskinesia (PCD) is a rare heterogenous condition that causes progressive suppurative lung disease, chronic rhinosinusitis, chronic otitis media, infertility and abnormal situs. ā€˜Better Experim...

    Authors: Florian Halbeisen, Claire Hogg, Mikkel C. Alanin, Zuzanna Bukowy-Bieryllo, Francisco Dasi, Julie Duncan, Amanda Friend, Myrofora Goutaki, Claire Jackson, Victoria Keenan, Amanda Harris, Robert A. Hirst, Philipp Latzin, Gemma Marsh, Kim Nielsen, Dominic Norris…
    Citation: BMC Proceedings 2018 12(Suppl 2):1
    Content type: Meeting report Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  41. Xavier University of Louisiana is a historically Black and Catholic university that is nationally recognized for its science, technology, engineering and mathematics (STEM) curricula. Approximately 73% of Xavi...

    Authors: Maryam Foroozesh, Marguerite Giguette, Kathleen Morgan, Kelly Johanson, Gene Dā€™Amour, Tiera Coston and Clair Wilkins-Green
    Citation: BMC Proceedings 2017 11(Suppl 12):28
    Content type: Original Paper Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  42. The National Institutes of Health (NIH)-funded Diversity Program Consortium (DPC) includes a Coordination and Evaluation Center (CEC) to conduct a longitudinal evaluation of the two signature, national NIH ini...

    Authors: Heather E. McCreath, Keith C. Norris, Nancy E. CalderĻŒn, Dawn L. Purnell, Nicole M. G. Maccalla and Teresa E. Seeman
    Citation: BMC Proceedings 2017 11(Suppl 12):27
    Content type: Method Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  43. UMBC, a diverse public research university, ā€œbuildsā€ upon its reputation in producing highly capable undergraduate scholars to create a comprehensive new model, STEM BUILD at UMBC. This program is designed to ...

    Authors: William R. LaCourse, Kathy Lee Sutphin, Laura E. Ott, Kenneth I. Maton, Patrice McDermott, Charles Bieberich, Philip Farabaugh and Philip Rous
    Citation: BMC Proceedings 2017 11(Suppl 12):24
    Content type: Original Paper Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  44. Faced with decades of severe economic decline, the city of Detroit, Michigan (USA) is on the cusp or reinventing itself. A Consortium was formed of three higher education institutions that have an established ...

    Authors: Jeanne M. Andreoli, Andrew Feig, Steven Chang, Sally Welch, Ambika Mathur and Gary Kuleck
    Citation: BMC Proceedings 2017 11(Suppl 12):23
    Content type: Original Paper Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  45. Unconscious bias and explicit forms of discrimination continue to pervade academic institutions. Multicultural and diversity training activities have not been sufficient in making structural and social changes...

    Authors: Carrie L. Saetermoe, Gabriela Chavira, Crist S. Khachikian, David Boyns and Beverly Cabello
    Citation: BMC Proceedings 2017 11(Suppl 12):21
    Content type: Original Paper Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  46. As part of the NIH BUILD initiative to diversify the scientific workforce, the EXITO project is a large multi-institutional effort to provide comprehensive support and training for undergraduates from traditio...

    Authors: Dawn M. Richardson, Thomas E. Keller, Deā€™ Sha S. Wolf, Adrienne Zell, Cynthia Morris and Carlos J. Crespo
    Citation: BMC Proceedings 2017 11(Suppl 12):19
    Content type: Original Paper Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  47. Undergraduate students who are interested in biomedical research typically work on a faculty memberā€™s research project, conduct one distinct task (e.g., running gels), and, step by step, enhance their skills. ...

    Authors: Farin Kamangar, Gillian Silver, Christine Hohmann, Cleo Hughes-Darden, Jocelyn Turner-Musa, Robert Trent Haines, Avis Jackson, Nelson Aguila and Payam Sheikhattari
    Citation: BMC Proceedings 2017 11(Suppl 12):18
    Content type: Original Paper Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  48. National reports call for improving Americaā€™s leadership in scientific research, accelerating degree attainments, and diversifying the scientific workforce to foster innovation. However, slow progress and pers...

    Authors: Sylvia Hurtado, Damani White-Lewis and Keith Norris
    Citation: BMC Proceedings 2017 11(Suppl 12):17
    Content type: Introduction Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  49. Preparing a successful research proposal is one of the most complex skills required of professional scientists, yet this skill is rarely if ever, taught. A major goal of the National Research Mentoring Network...

    Authors: Harlan P. Jones, Richard McGee, Anne Marie Weber-Main, Dedra S. Buchwald, Spero M. Manson, Jamboor K. Vishwanatha and Kolawole S. Okuyemi
    Citation: BMC Proceedings 2017 11(Suppl 12):16
    Content type: Original Paper Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

  50. The National Institutes of Health (NIH) funds training programs to increase the numbers and skills of scientists who obtain NIH research grants, but few programs have been rigorously evaluated. The sizeable re...

    Authors: Pamela L. Davidson, Nicole M. G. Maccalla, Abdelmonem A. Afifi, Lourdes Guerrero, Terry T. Nakazono, Shujin Zhong and Steven P. Wallace
    Citation: BMC Proceedings 2017 11(Suppl 12):15
    Content type: Method Published on:

    This article is part of a Supplement: Volume 11 Supplement 12

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