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  1. Meeting abstracts

    Proceedings of the International Workshop ‘Development of a National Diabetes Surveillance System in Germany – Core Indicators and Conceptual Framework’

    Andrea Teti, Lars Gabrys, Thomas Ziese, Christa Scheidt-Nave, Christin Heidemann, Lars Gabrys, Christian Schmidt, Andrea Teti, Ingrid-Katharina Wolf, Yong Du, Rebecca Paprott, Jens Baumert, Thomas Ziese, Christa Scheidt-Nave, Edward W. Gregg, Linda Geiss…

    BMC Proceedings 2017 11(Suppl 3):3

    Published on: 24 February 2017

    This article is part of a Supplement: Volume 11 Supplement 3

  2. Meeting Report

    The African cholera surveillance network (Africhol) consortium meeting, 10–11 June 2015, Lomé, Togo

    The fifth annual meeting of the African cholera surveillance network (Africhol) took place on 10–11 June 2015 in Lomé, Togo. Together with international partners, representatives from the 11 member countries -...

    Aline Munier, Berthe-Marie Njanpop-Lafourcade, Delphine Sauvageot, Raymond B. Mhlanga, Léonard Heyerdahl, Johara Nadri, Richard Wood, Issaka Ouedraogo, Alexandre Blake, Laurent Akilimali Mukelenge, Jean-Claude B. Anné, Abiba Banla Kere, Lucienne Dempouo, Sakoba Keita, José P. M. Langa, Issa Makumbi…

    BMC Proceedings 2017 11(Suppl 1):2

    Published on: 31 January 2017

    This article is part of a Supplement: Volume 11 Supplement 1

  3. Meeting Report

    Vaccination ecosystem health check: achieving impact today and sustainability for tomorrow

    Vaccination is a complex ecosystem with several components that interact with one another and with the environment. Today’s vaccine ecosystem is defined by the pursuit of polio eradication, the drive to get as...

    Mitra Saadatian-Elahi, David Bloom, Stanley Plotkin, Valentina Picot, Jacques Louis and Michael Watson

    BMC Proceedings 2017 11(Suppl 2):1

    Published on: 27 January 2017

    This article is part of a Supplement: Volume 11 Supplement 2

  4. Meeting report

    Proceedings of the COST action BM1407 inaugural conference BEAT-PCD: translational research in primary ciliary dyskinesia - bench, bedside, and population perspectives

    Primary ciliary dyskinesia (PCD) is a rare heterogenous condition that causes progressive suppurative lung disease, chronic rhinosinusitis, chronic otitis media, infertility and abnormal situs. ‘Better Experim...

    Bruna Rubbo, Laura Behan, Eleonora Dehlink, Myrofora Goutaki, Claire Hogg, Panayiotis Kouis, Claudia E. Kuehni, Philipp Latzin, Kim Nielsen, Dominic Norris, Sylvia Nyilas, Mareike Price and Jane S. Lucas

    BMC Proceedings 2016 10(Suppl 9):66

    Published on: 29 November 2016

    This article is part of a Supplement: Volume 10 Supplement 9

  5. Proceedings

    A general method for combining different family-based rare-variant tests of association to improve power and robustness of a wide range of genetic architectures

    Current rare-variant, gene-based tests of association often suffer from a lack of statistical power to detect genotype–phenotype associations as a result of a lack of prior knowledge of genetic disease models ...

    Alden Green, Kaitlyn Cook, Kelsey Grinde, Alessandra Valcarcel and Nathan Tintle

    BMC Proceedings 2016 10(Suppl 7):23

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  6. Proceedings

    Integrating multiple genomic data: sparse representation based biomarker selection for blood pressure

    Although many genes have been implicated as hypertension candidates, to date, few studies have integrated different types of genomic data for the purpose of biomarker selection.

    Hongbao Cao, Wei Guo, Haide Qin, Mengyuan Xu, Benjamin Lehrman, Yu Tao and Yin-Yao Shugart

    BMC Proceedings 2016 10(Suppl 7):40

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  7. Proceedings

    Transmission and decorrelation methods for detecting rare variants using sequencing data from related individuals

    Advances in whole genome sequencing have enabled the investigation of rare variants, which could explain some of the missing heritability that genome-wide association studies are unable to detect. Most methods...

    Burcu F. Darst and Corinne D. Engelman

    BMC Proceedings 2016 10(Suppl 7):46

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  8. Proceedings

    A clustering approach to identify rare variants associated with hypertension

    With the development of the next-generation sequencing technology, the influence of rare variants on complex disease has gathered increasing attention. In this paper, we propose a clustering-based approach, th...

    Rui Sun, Qiao Deng, Inchi Hu, Benny Chung-Ying Zee and Maggie Haitian Wang

    BMC Proceedings 2016 10(Suppl 7):24

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  9. Proceedings

    Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19

    The Genetic Analysis Workshops (GAW) are a forum for development, testing, and comparison of statistical genetic methods and software. Each contribution to the workshop includes an application to a specified d...

    John Blangero, Tanya M. Teslovich, Xueling Sim, Marcio A. Almeida, Goo Jun, Thomas D. Dyer, Matthew Johnson, Juan M. Peralta, Alisa Manning, Andrew R. Wood, Christian Fuchsberger, Jack W. Kent, David A. Aguilar, Jennifer E. Below, Vidya S. Farook, Rector Arya…

    BMC Proceedings 2016 10(Suppl 7):20

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  10. Proceedings

    Comparison of multiple single-nucleotide variant association tests in a meta-analysis of Genetic Analysis Workshop 19 family and unrelated data

    Meta-analysis has been widely used in genetic association studies to increase sample size and to improve power, both in the context of single-variant analysis, as well as for gene-based tests. Meta-analysis ap...

    Shuai Wang, Virginia A. Fisher, Yuning Chen and Josée Dupuis

    BMC Proceedings 2016 10(Suppl 7):51

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  11. Proceedings

    Genetic complexity at expression quantitative trait loci

    Identifying variants that regulate gene expression and delineating their genetic architecture is a critical next step in our endeavors to better understand the genetic etiology of complex diseases. The appropr...

    Rita M. Cantor, Calvin Pan and Kimberly Siegmund

    BMC Proceedings 2016 10(Suppl 7):37

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  12. Proceedings

    Structural equation modeling with latent variables for longitudinal blood pressure traits using general pedigrees

    Structural equation modeling (SEM) has been used in a wide range of applied sciences including genetic analysis. The recently developed R package, strum, implements a framework for SEM for general pedigree data. ...

    Yeunjoo E. Song, Nathan J. Morris and Catherine M. Stein

    BMC Proceedings 2016 10(Suppl 7):55

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  13. Proceedings

    Analysis of gene expression to predict dynamics of future hypertension incidence in type 2 diabetic patients

    The main focus of the Genetic Analysis Workshop 19 (GAW19) is identification of genes related to the occurrence of hypertension in the cohort of patients with type 2 diabetes mellitus (T2DM). The aim of our st...

    Piotr Radkowski, Gracjan Wątor, Jan Skupien, Anna Bogdali and Paweł Wołkow

    BMC Proceedings 2016 10(Suppl 7):64

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  14. Proceedings

    Prioritization of family member sequencing for the detection of rare variants

    The advent of affordable sequencing has enabled researchers to discover many variants contributing to disease, including rare variants. There are methods for determining the most informative individuals for se...

    Rachel Sippy, Jill M Kolesar, Burcu F Darst and Corinne D Engelman

    BMC Proceedings 2016 10(Suppl 7):11

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  15. Proceedings

    Association of polymorphisms in the aldosterone-regulated sodium reabsorption pathway with blood pressure among Hispanics

    Whereas genome-wide association study (GWAS) has proven to be an important tool for discovery of variants influencing many human diseases and traits, unfortunately its performance has not been much of all-arou...

    Bamidele O. Tayo, Liping Tong and Richard S. Cooper

    BMC Proceedings 2016 10(Suppl 7):15

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  16. Proceedings

    Comparing strategies for combined testing of rare and common variants in whole sequence and genome-wide genotype data

    We used our extension of the kernel score test to family data to analyze real and simulated baseline systolic blood pressure in extended pedigrees. We compared the power for different kernels and for different...

    Dörthe Malzahn, Stefanie Friedrichs and Heike Bickeböller

    BMC Proceedings 2016 10(Suppl 7):17

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  17. Proceedings

    Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test

    We present a novel approach to detect potential cis-acting regulatory loci that combines the functional potential, an empirical DNase-seq based estimate of the allele-specificity of DNase-I hypersensitivity sites...

    Juan Manuel Peralta, Marcio Almeida, Lawrence J. Abraham, Eric Moses and John Blangero

    BMC Proceedings 2016 10(Suppl 7):50

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  18. Proceedings

    Identity-by-descent mapping for diastolic blood pressure in unrelated Mexican Americans

    Population-based identity by descent (IBD) mapping is a statistical method for detection of genetic loci that share an ancestral segment among “unrelated” pairs of individuals for a disease. As a complementary...

    Xiao-Qing Liu, Jillian Fazio, Pingzhao Hu and Andrew D. Paterson

    BMC Proceedings 2016 10(Suppl 7):8

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

  19. Proceedings

    Independent test assessment using the extreme value distribution theory

    The new generation of whole genome sequencing platforms offers great possibilities and challenges for dissecting the genetic basis of complex traits. With a very high number of sequence variants, a naïve multi...

    Marcio Almeida, Lucy Blondell, Juan M. Peralta, Jack W. Kent, Goo Jun, Tanya M. Teslovich, Christian Fuchsberger, Andrew R. Wood, Alisa K. Manning, Timothy M. Frayling, Pablo E. Cingolani, Robert Sladek, Thomas D. Dyer, Goncalo Abecasis, Ravindranath Duggirala and John Blangero

    BMC Proceedings 2016 10(Suppl 7):63

    Published on: 18 October 2016

    This article is part of a Supplement: Volume 10 Supplement 7

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