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Table 1 Summary of ordered subset linkage analysis

From: A genome-wide ordered-subset linkage analysis for rheumatoid arthritis

    Max No. families Covariate range   
Covariates Chr. no. Linkage peak (cM)a Newb Oldc Deltad p-Value (Delta Max)e With defined covariate values In best ordered subsetf Bestg Totalh p-Value (Permutations) 95% CI
Age of onset 4 102.03 4.45 3.55 0.9 0.012 606 +472 [31.5–83.0] [11.0–83.0] 0.021 [0.0078, 0.0194]
  9 0.59 2.85 1.18 1.67 0.022 606 +27 [59.5–83.0] [11.0–83.0] 0.022 [0.0141, 0.0349]
Anti-CCP level 2 154.17 3.72 2.83 0.9 0.048 590 +219 [133–413] [0.8–413] -0.951 [0.0302, 0.0742]
  18 26.29 3.73 2.46 1.27 0.022 590 +40 [234–413] [0.8–413] 0.022 [0.0138, 0.0342]
  19 52.22 3.27 1.01 2.26 0.009 590 -10 [0.8–3.50] [0.8–413] 0.009 [0.0057, 0.0142]
  1. a Location of maximum score, maximized over all ordered subsets.
  2. b Maximum score, maximized over all loci and ordered subsets.
  3. c Maximum score using all families with a covariate value, maximized over all loci.
  4. d Delta Max = (New Max) - (Old Max)
  5. e Probability of observing a change in LOD score greater than or equal to delta max if family linkage scores and family covariate scores are independent.
  6. f + or -, the best ordered subset consists of families with the highest (+) or lowest (-) covariate scores.
  7. g Range of covariate values in the ordered subset with highest linkage score.
  8. h Range of covariate scores in the set of all families.