Genome-wide analysis of single-locus and epistasis single-nucleotide polymorphism effects on anti-cyclic citrullinated peptide as a measure of rheumatoid arthritis

Table 3 Significant SNP epistasis effects on square root transformed anti-CCP with p < 10^-7

Chromosome 1	SNP1	Chromosome 2	SNP2	Effect^a	p-Value
1	rs2031750	18	rs1395610	A × A	0.827 × 10^-7
2	rs1261238	23	rs953114	D × A	0.976 × 10^-7
6	rs310389	13	rs4941527	I	0.563 × 10^-7
6	rs310389	13	rs4941527	D × A	0.765 × 10^-7
6	rs873460	16	rs874562	A × A	0.754 × 10^-7
6	rs1087924	23	rs644429	I	0.583 × 10^-7
7	rs2056553	10	rs1328327	D × A	0.583 × 10^-8
11	rs1009172	23	rs17410	I	0.612 × 10^-9
11	rs1009172	23	rs17410	A × A	0.247 × 10^-10
12	rs1400142	14	rs1959068	D × D	0.437 × 10^-7

^aI, two-locus interaction effect; A × A, additive × additive effect; A × D, additive × dominance effect; D × A, dominance × additive effect; D × D, dominance × dominance effect.

ISSN: 1753-6561