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Table 3 Significant SNP epistasis effects on square root transformed anti-CCP with p < 10-7

From: Genome-wide analysis of single-locus and epistasis single-nucleotide polymorphism effects on anti-cyclic citrullinated peptide as a measure of rheumatoid arthritis

Chromosome 1 SNP1 Chromosome 2 SNP2 Effecta p-Value
1 rs2031750 18 rs1395610 A × A 0.827 × 10-7
2 rs1261238 23 rs953114 D × A 0.976 × 10-7
6 rs310389 13 rs4941527 I 0.563 × 10-7
6 rs310389 13 rs4941527 D × A 0.765 × 10-7
6 rs873460 16 rs874562 A × A 0.754 × 10-7
6 rs1087924 23 rs644429 I 0.583 × 10-7
7 rs2056553 10 rs1328327 D × A 0.583 × 10-8
11 rs1009172 23 rs17410 I 0.612 × 10-9
11 rs1009172 23 rs17410 A × A 0.247 × 10-10
12 rs1400142 14 rs1959068 D × D 0.437 × 10-7
  1. aI, two-locus interaction effect; A × A, additive × additive effect; A × D, additive × dominance effect; D × A, dominance × additive effect; D × D, dominance × dominance effect.