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Table 3 Performance of the multiple-marker strategy in disease severity analysis

From: A two-step multiple-marker strategy for genome-wide association studies

Correction for multiple testing FBAT LC % of severity loci detectedb
  Sensitivitya Specificitya FDRa  
Without correction 1.00 (0.00) 0.92 (0.03) 0.75 (0.13) 0.91 (0.19)
Benjamini & Hochberg 0.96 (0.20) 0.99 (0.01) 0.14 (0.24) 0.87 (0.26)
Bonferroni 0.96 (0.20) 0.99 (0.01) 0.14 (0.24) 0.87 (0.26)
  1. aMean (standard deviation) of sensitivity, specificity and false-discovery rate of FBAT-LC test computed over 50 replicates of family data when 50 regions were selected in Step 1.
  2. bMean (standard deviation) of the proportion of severity loci selected in Step 1 and detected in Step 2 by FBAT at the 5% level over 50 replicates when 50 regions were selected in Step 1.