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Table 4 Problem 1 empirical power computed under the polygenic trait model power with varying heritability and proportion of genetic variance due to polygenes (t)

From: One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies

  Powera
  t = 0.2 t = 0.5
  h2 = 0.5 h2 = 0.8 h2 = 0.5 h2 = 0.8
2-stage (n = 10) 0.58 0.83 0.15 0.26
1-stage CLRT (n = 1509) 0.99 1 0.73 0.97
  1. aNominal type I error rate of α = 0.05, using a Bonferroni correction