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Table 1 Definition of study designsa

From: Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies

Design Linkage software Case selection strategy Notes
A MERLIN All  
B MERLIN "LINKED BEST" [5]  
C MERLIN plus OSA OSA subset if ≥50 families OSA for localization
D MERLIN-REGRESS All  
E MERLIN-REGRESS (M-R) plus OSA OSA subset if ≥50 families and difference in OSA and M-R peak ≤20 cM M-R for localization
  1. aLinkage region is centered on maximum LOD score (for all families or OSA subset) and defines SNPs for Stage 2 association analysis.