| | |
Proportion of reps. meeting:
| | | | |
|---|
| | |
Linkage threshold
|
Association threshold (avg. no. SNPs analyzed)c
|
Avg. no. cases analyzed
|
Overall power
|
|---|
| | |
Stringenta
|
Looseb
|
Stringent
|
Loose
|
Stringent
|
Loose
|
Stringent
|
Loose
|
|---|
|
9 (186)
|
A
|
0
|
0.14
|
0 (n/a)
|
0 (144)
|
1500
|
1500
|
0
|
0
|
| |
B
|
0
|
0.14
|
0 (n/a)
|
0 (144)
|
983
|
987
|
0
|
0
|
| |
C
|
0.13
|
0.64
|
0.23 (48)
|
0.25 (145)
|
127
|
136
|
0.03
|
0.16
|
| |
D
|
0.83
|
0.96
|
0.01 (48)
|
0 (147)
|
1500
|
1500
|
0.01
|
0
|
| |
E
|
0.2
|
0.65
|
0.30 (48)
|
0.20 (148)
|
129
|
121
|
0.06
|
0.13
|
|
11 (389)
|
A
|
0.06
|
0.24
|
1 (52)
|
1 (147)
|
1500
|
1500
|
0.06
|
0.24
|
| |
B
|
0.06
|
0.24
|
1 (52)
|
1 (147)
|
988
|
985
|
0.06
|
0.24
|
| |
C
|
0.11
|
0.62
|
1 (48)
|
0.92 (147)
|
258
|
273
|
0.11
|
0.57
|
| |
D
|
0.98
|
1
|
1 (44)
|
1 (146)
|
1500
|
1500
|
0.98
|
1
|
| |
E
|
0.23
|
0.56
|
1 (46)
|
1 (147)
|
281
|
290
|
0.23
|
0.56
|
|
18 (269)
|
A
|
0.21
|
0.64
|
1 (28)
|
1 (97)
|
1500
|
1500
|
0.21
|
0.64
|
| |
B
|
0.21
|
0.64
|
1 (28)
|
1 (97)
|
998
|
988
|
0.21
|
0.64
|
| |
C
|
0.53
|
0.91
|
1 (28)
|
1 (96)
|
372
|
390
|
0.53
|
0.91
|
| |
D
|
0.73
|
0.99
|
1 (27)
|
1 (95)
|
1500
|
1500
|
0.73
|
0.99
|
| |
E
|
0.44
|
0.88
|
1 (27)
|
1 (95)
|
370
|
382
|
0.44
|
0.88
|
- aStringent linkage thresholds are LOD score ≥ 1.0, OSA p-value ≤ 0.05, 10-cM linkage region.
- bLoose thresholds are LOD score ≥ 0.5, OSA p-value ≤ 0.5, 40-cM linkage region.
- cThe proportion of replicates meeting the Bonferroni-corrected association threshold, average number of cases and number of SNPs analyzed were calculated across replicates meeting the linkage threshold.
