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Table 3 Power estimates for study designs

From: Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies

   Proportion of reps. meeting:     
   Linkage threshold Association threshold (avg. no. SNPs analyzed)c Avg. no. cases analyzed Overall power
   Stringenta Looseb Stringent Loose Stringent Loose Stringent Loose
9 (186) A 0 0.14 0 (n/a) 0 (144) 1500 1500 0 0
  B 0 0.14 0 (n/a) 0 (144) 983 987 0 0
  C 0.13 0.64 0.23 (48) 0.25 (145) 127 136 0.03 0.16
  D 0.83 0.96 0.01 (48) 0 (147) 1500 1500 0.01 0
  E 0.2 0.65 0.30 (48) 0.20 (148) 129 121 0.06 0.13
11 (389) A 0.06 0.24 1 (52) 1 (147) 1500 1500 0.06 0.24
  B 0.06 0.24 1 (52) 1 (147) 988 985 0.06 0.24
  C 0.11 0.62 1 (48) 0.92 (147) 258 273 0.11 0.57
  D 0.98 1 1 (44) 1 (146) 1500 1500 0.98 1
  E 0.23 0.56 1 (46) 1 (147) 281 290 0.23 0.56
18 (269) A 0.21 0.64 1 (28) 1 (97) 1500 1500 0.21 0.64
  B 0.21 0.64 1 (28) 1 (97) 998 988 0.21 0.64
  C 0.53 0.91 1 (28) 1 (96) 372 390 0.53 0.91
  D 0.73 0.99 1 (27) 1 (95) 1500 1500 0.73 0.99
  E 0.44 0.88 1 (27) 1 (95) 370 382 0.44 0.88
  1. aStringent linkage thresholds are LOD score ≥ 1.0, OSA p-value ≤ 0.05, 10-cM linkage region.
  2. bLoose thresholds are LOD score ≥ 0.5, OSA p-value ≤ 0.5, 40-cM linkage region.
  3. cThe proportion of replicates meeting the Bonferroni-corrected association threshold, average number of cases and number of SNPs analyzed were calculated across replicates meeting the linkage threshold.