Table 1 Estimating p0 and average effect size with different methods using all 100 replicates
From: Estimating the number and size of the main effects in genome-wide case-control association studies
p0 Estimates | Average effect size estimates | ||||
|---|---|---|---|---|---|
No. times p0 = 1 | Mean | Std. dev. | Mean | Std. dev. | |
Quasi-maximum likelihood | 0 | 0.998425 | 1.97 × 10-4 | 0.083 | 5.10 × 10-3 |
Maximum likelihood | 0 | 0.998424 | 1.92 × 10-4 | 0.083 | 4.92 × 10-3 |
Conservative (k = 1) | 0 | 0.998409 | 1.72 × 10-4 | 0.083 | 4.94 × 10-3 |
Adaptive conservative | 0 | 0.998425 | 2.12 × 10-4 | 0.083 | 5.09 × 10-3 |
Lowest slope | 0 | 0.998162 | 2.99 × 10-4 | 0.082 | 5.09 × 10-3 |
Storey-Tibshirani | 38 | 0.984106 | 1.87 × 10-2 | 0.052 | 2.79 × 10-2 |
Storeya | 2 | 0.972607 | 2.59 × 10-2 | 0.051 | 2.75 × 10-2 |
Location based estimator | 100 | 1 | 0 | --- | --- |