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Table 1 Power of haplotype- and cluster-based association analyses at the HLA-DRB1 locusa

From: Density-based clustering in haplotype analysis for association mapping

  Powerb  
  α = 0.05 α = 0.01 Mean d.f.c
6 Markers d    
   Haplotypes 0.672 0.379 9.36
   Clusters 0.812 0.593 3.65
8 Markers e    
   Haplotypes 0.654 0.356 10.07
   Clusters 0.822 0.597 3.94
  1. aSex and number of DRB1*04 alleles were included as covariates in all analyses.
  2. bProportion of 1000 data sets of 150 each cases and controls giving p-values below nominal α.
  3. cMean degrees of freedom from the score test for association.
  4. dSNPs 3435–3440.
  5. eSNPs 3433, 3435–3441.