Joint analysis of case-parents trio and unrelated case-control designs in large scale association studies

BMC Proceedings

Table 1 Conditional probabilities of genotype given parental mating types and offspring disease status

Parental mating type	Case genotype	Count	Probability of trio	Conditional probability
1) MM × MM	MM	n ₁₂	p⁴ψ₂/T	1
2) MM × NM	MM	n ₂₂	2p³q(ψ₁ + ψ₂)/T	ψ₂/(ψ₁ + ψ₂)
	NM	n ₂₁		ψ₁/(ψ₁ + ψ₂)
3) MM × NN	NM	n ₃₁	2p²q²ψ₁/T	1
4) NM × NM	MM	n ₄₂	2p²q²(ψ₂ + 2ψ₁ + 1)/T	ψ₂/(ψ₂ + 2ψ₁ + 1)
	NM	n ₄₁		2ψ₁/(ψ₂ + 2ψ₁ + 1)
	NN	n ₄₀		1/(ψ₂ + 2ψ₁ + 1)
5) NM × NN	NM	n ₅₁	2pq³(ψ₁ + 1)/T	ψ₁/(ψ₁ + 1)
	NN	n ₅₀		1/(ψ₁ + 1)
6) NN × NN	NN	n ₆₀	q⁴1/T	1

ISSN: 1753-6561