Genetic Analysis Workshop 15: simulation of a complex genetic model for rheumatoid arthritis in nuclear families including a dense SNP map with linkage disequilibrium between marker loci and trait loci

Table 1 Effects of major genes

Locus	Chr	cM	Trait locus effect
DR	6	49.4556	Affects directly the risk of RA
A	16	26.2879	Controls effect of DR on RA risk
B	8	170.9087	Controls effect of smoking on RA risk
C	6	49.4556	0 cM from DR, increases RA risk only in women
D	6	54.5717^a	5.12^a cM from DR, rare allele increases RA risk 5-fold
E	18	94.2729	Controls effect of DR on anti-CCP and increases RA risk
F	11	115.2864	QTL for IgM
G	9	49.3955	2 cM from Locus H, is 25% QTL for severity
H	9	51.4134^a	2 cM from Locus G, is 25% QTL for severity

^aThese incorrect positions were reported to GAW participants. The correct positions are for Locus D: 59.4756 cM, 10.02 cM from Locus DR/C, and for Locus H: 51.2555 cM which is 1.86 cM from Locus G.

ISSN: 1753-6561