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Table 2 A list of GO molecular function categories highly significantly (p ≤ 0.01) enriched with genes of high familial aggregations

From: Familial aggregation analysis of gene expressions

GO ID GO Description n a m b p
GO:0000166 nucleotide binding 468 202 6.15 × 10-7
GO:0003735 structural constituent of ribosome 54 5 2.5 × 10-5
GO:0003723 RNA binding 177 83 4.64 × 10-5
GO:0004872 receptor activity 174 37 9.95 × 10-5
GO:0005509 calcium ion binding 150 31 0.000154
GO:0051082 unfolded protein binding 66 36 0.000187
GO:0005524 ATP binding 377 152 0.000578
GO:0005515 protein binding 880 264 0.001239
GO:0004004 ATP-dependent RNA helicase activity 6 6 0.001397
GO:0016874 ligase activity 73 35 0.003392
GO:0003779 actin binding 57 10 0.003461
GO:0003700 transcription factor activity 232 63 0.005974
GO:0004842 ubiquitin-protein ligase activity 31 17 0.007186
GO:0003676 nucleic acid binding 80 36 0.008773
GO:0005506 iron ion binding 57 27 0.009803
  1. an, Number of genes contained in a category identified and counted by using set A (a total of 3300 genes).
  2. bm, Number of (highly familially aggregated) genes contained in the category, counted using set B (a total of 1105 genes).