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Table 1 Highest two-locus peaks on the 2D surface

From: A two-dimensional genome scan for rheumatoid arthritis susceptibility loci

    Two-locus resultsa
Locus 1 Θ Locus 2 GEN (microsatellite) GEN-ADD P-value GEN-MUL P-value εb GENc (microsatellite and SNP) 1-Lod unit support intervals (cM)d
Entire 2D surface
6p21 0.5 16p12 18.02 0.011 0.011 103 21.86 (51–55); (37–59)
6p21 0.5 18q21 17.90 0.254 0.937 0.66 23.04 (51–55); (52–85)
6p21 0.5 8p23 17.85 0.036 0.413 8.12 22.27 (51–55); (0–26)
1q42 0.5 6p21 17.44 0.642 0.083 0 21.58 (221–270); (51–55)
6p22 0.11 6p21 17.44 0.999 0.009 0 21.5 (31–47); (51–58)
2D surface excluding 6p21 interactions
8p23 0.5 18q21 4.60 0.631 0.587 0 3.24 (0–26); (52–85)
1p21 0.5 18q21 4.33 0.114 0.410 53 3.42 (126–153); (26–85)
  1. aTwo-locus general model MLS obtained in 511 families with microsatellite genotypes alone. Empirical P-values assessing the significance of the difference in two-locus MLS under the general and additive models, and the general and multiplicative models. Significant deviations from the null two-locus model (ADD or MUL) are shown in bold. Empirical P-values were also obtained assuming a null effect at the two loci using published thresholds [3], and for pairs of loci excluding 6p21 these were estimated at P = 0.34 for 8p23-18q21, and P = 0.53 for 1p21-18q21.
  2. bMaximum-likelihood estimate of epsilon.
  3. cTwo-locus general model MLS in 744 families using combined microsatellite and SNP data.
  4. d1-Lod unit support intervals (to nearest Rutgers Kosambi cM) obtained using the GEN statistic from the microsatellite data set.