Skip to main content

Table 2 Power and estimates of interaction coefficients of the four tests over 100 replicates

From: Power comparison of different methods to detect genetic effects and gene-environment interactions

  Power (%)a Average interaction coefficients [95% CI]
Test G+I G I IBb IBB
Mean interaction test 6 8 12 - -
Log-linear-modelingb 87 78 53 1.33 [1.03–1.71] 1.72 [1.13–1.83]
Case-controlb 98 95 69 1.39 [0.97–1.96] 1.88 [1.08–3.10]
Case-onlyb - - 95 1.39 [1.05–1.72] 1.86 [1.39–2.96]
Log-linear-modelingc 33 23 20 1.35 [0.79–2.15] 1.79 [0.82–3.68]
Case-controld 79 68 42 1.41 [0.85–2.09] 1.96 [0.99–3.37]
  1. a G+I, genetic effect accounting for interaction; G, genetic effect not accounting for interaction; I, G × E interaction.
  2. b Samples of 1500 families were used corresponding to 4500 (1500 triads), 3000 (1500 cases and 1500 controls), and 1500 genotyped individuals for the log-linear-modeling, the case-control and the case-only design, respectively.
  3. c Samples of 500 triads are considered corresponding to 1500 genotyped individuals.
  4. dSamples of 750 cases and 750 controls are considered here to limit the number of genotyped individuals to 1500.