Figure 1

The regulatory program. Definition of the regulatory program RP, which can be interpreted as follows: i) If GRN contains co-activators only, $\widehat{g}$(A, I) corresponds to the aggregated status of these co-activators. ii) If GRN contains co-inhibitors only, $\widehat{g}$(A, I) is the inverse of the aggregated status of these co-inhibitors. iii) Otherwise, $\widehat{g}$(A, I) depends on a combination of the statuses of co-activators and co-inhibitors, as described by the matrix on the right. For example, $\widehat{g}$(A, I) = 1 when the co-activators are over-expressed and the co-inhibitors are not.