Volume 2 Supplement 1

Infectious diseases of the nervous system: pathogenesis and worldwide impact

Open Access

Differential invasion of Trypanosoma brucei bruceiand lymphocytes into the brain of C57BL/6

  • Willias Masocha1Email author,
  • Daniel N Amin2,
  • Krister Kristensson2 and
  • Martin E Rottenberg3
BMC Proceedings20082(Suppl 1):P38

https://doi.org/10.1186/1753-6561-2-s1-p38

Published: 23 September 2008

Trypanosoma brucei (T. b.) subspecies invade the brain parenchyma at late stages of human and experimental rodent infections. Here, we compared the outcome of infection with T. b. in MHC-matched (H2b) C57BL/6 (B6) and 129Sv/Ev (Sv-129). While Sv-129 showed higher parasitemia and lower specific IgM (but not IgG) antibody levels than B6 mice, the number of trypanosomes, CD4+ and CD8+ T cells in the brain parenchyma was higher in B6 mice. B6 mice lost weight and showed higher cumulative mortality compared to Sv-129 mice. Higher levels of IL-1β, IL-6, IL-10, TNF-α, IFN-γ, ICAM-1 and E-selectin, but low levels of TGF-β mRNA were present in brains of B6 compared to Sv-129-infected mice. Thus, host genetics differentially determine invasion of T. b. brucei into the brain parenchyma, which is paralleled by the severity of inflammation in the brain and course of the disease, but not by parasitemia or antibody titers.

Declarations

Acknowledgements

This study was supported by a grant from the European Union (NEUROTRYP; FP6-2004-INCO-DEV-3 032324), the Swedish International Developing Agency (SIDA) and WHO-TDR.

Authors’ Affiliations

(1)
Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University
(2)
Department of Neuroscience, Karolinska Institutet
(3)
Department of Microbiology & Tumor Biology Center, Karolinska Institutet

Copyright

© Masocha et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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