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Differential kinetics of plasma procalcitonin levels in cerebral malaria in urban Senegalese patients according to disease outcome

  • Babacar Mbengue1Email author,
  • Bacary Diatta2,
  • Birahim Niang2,
  • Ngor Diagne1,
  • Mamadou Ndiaye2,
  • Laurence Marrama1,
  • Olivier Garraud3,
  • Ronald Perraut1 and
  • Alioune Dieye1
BMC Proceedings20082(Suppl 1):P40

https://doi.org/10.1186/1753-6561-2-s1-p40

Published: 23 September 2008

Keywords

Clinical OutcomeSerum LevelMalariaThreshold LevelStudy Analyse

P. falciparum malaria is directly responsible for near two million lives a year, and one is still on the quest for a prognostic marker of fatal outcome. This study analyses the association between serum levels of Procalcitonin (PCT), a marker of septic inflammation, and clinical outcome in 98 Senegalese patients, hospitalised with cerebral malaria.

Mean PCT levels were more elevated in patients with active infection, significantly higher on day 0 and onwards in the 26.5% of fatal cases, compared to that survivors (53.6 vs 27.3; P = 0.01). No clearly defined threshold level indicated an individual occurrence of fatality, however there was a clear different profile of evolution of PCT levels on the 3 days of observation: they significantly decreased by day 1 in surviving patients (P < 0.001), contrary to fatal cases, indicating that PCT level and kinetics could be of use to predict a reduced risk of fatality in patient with cerebral malaria.

Authors’ Affiliations

(1)
Unité d'Immunologie, Institut Pasteur de Dakar, Sénégal
(2)
Hôpital Principal de Dakar, Service de Réanimation, Av Nelson Mandela, Sénégal
(3)
GIMAP – EA 3064, Faculty of Medicine, University of Saint-Etienne, France

Copyright

© Mbengue et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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