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Differential kinetics of plasma procalcitonin levels in cerebral malaria in urban Senegalese patients according to disease outcome

  • Babacar Mbengue1Email author,
  • Bacary Diatta2,
  • Birahim Niang2,
  • Ngor Diagne1,
  • Mamadou Ndiaye2,
  • Laurence Marrama1,
  • Olivier Garraud3,
  • Ronald Perraut1 and
  • Alioune Dieye1
BMC Proceedings20082(Suppl 1):P40

Published: 23 September 2008


Clinical OutcomeSerum LevelMalariaThreshold LevelStudy Analyse

P. falciparum malaria is directly responsible for near two million lives a year, and one is still on the quest for a prognostic marker of fatal outcome. This study analyses the association between serum levels of Procalcitonin (PCT), a marker of septic inflammation, and clinical outcome in 98 Senegalese patients, hospitalised with cerebral malaria.

Mean PCT levels were more elevated in patients with active infection, significantly higher on day 0 and onwards in the 26.5% of fatal cases, compared to that survivors (53.6 vs 27.3; P = 0.01). No clearly defined threshold level indicated an individual occurrence of fatality, however there was a clear different profile of evolution of PCT levels on the 3 days of observation: they significantly decreased by day 1 in surviving patients (P < 0.001), contrary to fatal cases, indicating that PCT level and kinetics could be of use to predict a reduced risk of fatality in patient with cerebral malaria.

Authors’ Affiliations

Unité d'Immunologie, Institut Pasteur de Dakar, Sénégal
Hôpital Principal de Dakar, Service de Réanimation, Av Nelson Mandela, Sénégal
GIMAP – EA 3064, Faculty of Medicine, University of Saint-Etienne, France


© Mbengue et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.