Volume 2 Supplement 1

Infectious diseases of the nervous system: pathogenesis and worldwide impact

Open Access

Comparison of operational criteria for treatment outcome in gambiense human African trypanosomiasis

  • Dieudonné Mumba Ngoyi1, 2Email author,
  • Veerle Lejon2,
  • François Xavier N'Siesi3,
  • Marleen Boelaert2 and
  • Philippe Büscher2
BMC Proceedings20082(Suppl 1):P48


Published: 23 September 2008

Sleeping sickness or human African trypanosomiasis in West and Central Africa is caused by Trypanosoma brucei gambiense. The infection progresses from a haemo-lymphatic or first stage to a meningo-encephalitic or second stage, once parasites reach the central nervous system. After treatment, trypanosomiasis patients should be followed for 2 years before they can be considered cured. Relapse after treatment is unambiguously diagnosed by the presence of trypanosomes in blood, lymph and/or cerebrospinal fluid. If trypanosomes are not detected, diagnosis of relapse is based on the absolute number of, and/or increase in white blood cells in cerebrospinal fluid with or without neurological symptoms. Currently, white blood cell count based criteria to define relapse or cure are not standardized. As a consequence, the impact of the different criteria for relapse on the outcome and comparability of clinical trials remains unknown.

The specificity, sensitivity and time to diagnosis of 10 criteria for relapse based on trypanosome detection and/or the white blood cell count in cerebrospinal fluid were compared in 63 relapsed and 247 cured Trypanosoma brucei gambiense patients. Among the criteria in use, the "presence of trypanosomes or a cerebrospinal white blood cell count ≥ 50/μl" can be recommended as the criterion to identify relapses after treatment for Trypanosoma brucei gambiense human African trypanosomiasis, irrespective of disease stage.

Authors’ Affiliations

Service Parasito 2, Institut National de Recherche Biomédicale
Deptartments of Parasitology and Public Health, Institute of Tropical Medicine
Ministry of Health


© Ngoyi et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.