Figure 1

The process of combining QTL and gene expression results. Panel A shows the two areas of comparing gene expression results with QTL results: 1) co-location at the genome level between differentially expressed genes and QTL, 2) significant overlap at the pathway level between genes in the QTL region and differentially expressed genes elsewhere in the genome. Panel B illustrates the steps to test for co-location between differentially expressed genes and QTL regions in the pig example. The solid arrows indicate the comparisons at the level of the pig genome. The dashed arrows outline an alternative strategy where comparisons are made on the human genome, using comparative mapping approaches. Panel C illustrates the steps that are required to test for significant enrichment at the pathway level between differentially expressed genes and genes in the QTL region.