Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic

Table 1 Type I error

	LDL---Visit 1				TG---Average
	0.050	0.010	0.0010	0.00010	0.050	0.010	0.0010	0.00010
LRT (additive)
MAF>1%	0.048	0.012	0.0019	0.00010	0.051	0.012	0.0013	0.00015
MAF>10%	0.047	0.012	0.0018	0.00013	0.050	0.012	0.0010	0.00013
LRT (general 2 df)
MAF>1%	0.053	0.012	0.0012	0.00031	0.055	0.015	0.0039	0.00191
MAF>10%	0.050	0.011	0.0011	0.00025	0.050	0.012	0.0009	0.00013
Association conditional score (additive)
MAF>1%	0.045	0.010	0.0013	0.00005	0.050	0.010	0.0012	0.00010
MAF>10%	0.044	0.009	0.0014	0.00006	0.048	0.010	0.0009	0.00013
Association conditional score (general 2 df)
MAF>1%	0.065	0.016	0.0029	0.00118	0.073	0.023	0.0060	0.00282
MAF>10%	0.061	0.014	0.0013	0.00019	0.067	0.017	0.0021	0.00031

ISSN: 1753-6561