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Table 2 Percent of r2 > 0.8 of the 80 random samples of independent individuals by sample size, compared to percent of r2 > 0.8 for the 332 trios

From: Linkage disequilibrium of single-nucleotide polymorphism data: how sampling methods affect estimates of linkage disequilibrium

Distance bin (kb)

Range and mean ± SD

 
 

n= 25

n= 30

n= 40

n= 50

n= 100

n= 150

n= 200

n= 300

332 trios

0 - 5

26.9-28.5

26.7-28.1

26.0-27.4

23.7-26.8

25.4-27.0

26.6-27.0

26.7-27.1

26.9-27.1

27.7

 

27.7 ± 0.3

27.4 ± 0.3

26.7 ± 0.2

26.1 ± 0.7

26.4 ± 0.4

26.8 ± 0.3

26.9 ± 0.1

27.0 ± 0.04

 

5 - 10

16.8-17.9

16.5-17.5

15.8-16.8

14.0-16.6

15.3-16.5

16.0-16.6

16.1-16.4

16.3-16.5

17.1

 

17.2 ± 0.2

16.9 ± 0.2

16.4 ± 0.2

15.9 ± 0.5

16.0 ± 0.3

16.3 ± 0.2

16.3 ± 0.1

16.4 ± 0.04

 

10 - 15

12.4-13.3

12.1-13.0

11.6-12.5

10.1-12.2

11.0-12.0

11.5-12.0

11.6-11.9

11.8-11.9

12.4

 

12.8 ± 0.2

12.5 ± 0.2

12.0 ± 0.2

11.6 ± 0.4

11.6 ± 0.2

11.7 ± 0.2

11.8 ± 0.1

11.8 ± 0.04

 

15 - 20

9.72-10.7

9.52-10.3

9.06-9.79

7.94-9.53

8.45-9.33

8.91-9.34

9.02-9.28

9.09-9.27

9.84

 

10.1 ± 0.2

9.86 ± 0.18

9.41 ± 0.14

9.06 ± 0.38

9.00 ± 0.20

9.14 ± 0.20

9.15 ± 0.06

9.18 ± 0.04

 

20 - 25

7.68-8.40

7.34-8.10

7.06-7.65

6.06-7.47

6.46-7.19

6.89-7.22

6.94-7.16

7.02-7.15

7.61

 

7.95 ± 0.19

7.73 ± 0.15

7.36 ± 0.12

6.98 ± 0.30

6.86 ± 0.18

7.04 ± 0.17

7.05 ± 0.05

7.08 ± 0.03

 

25 - 40

5.24-5.70

5.07-5.52

4.85-5.21

4.14-5.10

4.22-4.90

4.64-4.83

4.68-4.82

4.72-4.82

5.07

 

5.50 ± 0.10

5.33 ± 0.09

5.03 ± 0.08

4.75 ± 0.20

4.62 ± 0.13

4.75 ± 0.11

4.75 ± 0.03

4.78 ± 0.02

 

40 - 60

3.09-3.52

3.00-3.41

2.84-3.17

2.44-3.11

2.44-2.86

2.70-2.85

2.70-2.81

2.73-2.79

2.88

 

3.31 ± 0.08

3.19 ± 0.09

2.99 ± 0.07

2.81 ± 0.13

2.70 ± 0.09

2.77 ± 0.07

2.76 ± 0.02

2.76 ± 0.01

 

60 - 80

1.91-2.25

1.84-2.13

1.72-1.96

1.48-1.89

1.41-1.68

1.58-1.69

1.55-1.66

1.59-1.65

1.73

 

2.06+0.07

1.97 ± 0.07

1.83 ± 0.06

1.69 ± 0.08

1.57 ± 0.06

1.63 ± 0.05

1.61 ± 0.2

1.62 ± 0.01

 

80 - 100

1.30-1.58

1.25-1.50

1.18-1.34

1.05-1.28

0.97-1.17

1.06-1.17

1.07-1.15

1.09-1.13

1.15

 

1.43 ± 0.05

1.36. ± 05

1.26 ± 0.04

1.17 ± 0.05

1.08 ± 0.04

1.11 ± 0.03

1.11 ± 0.02

1.11 ± 0.01

 

100 - 120

0.87-1.10

0.83-1.02

0.77-0.94

0.69-0.92

0.60-0.79

0.66-0.74

0.67-0.73

0.68-0.72

0.74

 

0.98 ± 0.05

0.92 ± 0.04

0.84 ± 0.04

0.79 ± 0.04

0.71 ± 0.04

0.71 ± 0.03

0.70 ± 0.01

0.70 ± 0.009

 

120 - 140

0.62-0.83

0.60-0.75

0.55-0.69

0.47-0.63

0.39-0.57

0.46-0.54

0.46-0.53

0.48-0.52

0.54

 

0.72 ± 0.04

0.68 ± 0.03

0.62 ± 0.03

0.57 ± 0.03

0.50 ± 0.03

0.51 ± 0.02

0.50 ± 0.01

0.49 ± 0.007

 

140 - 160

0.42-0.57

0.41-0.53

0.37-0.47

0.32-0.48

0.28-0.37

0.30-0.37

0.32-0.36

0.32-0.36

0.34

 

0.49 ± 0.03

0.46 ± 0.03

0.42 ± 0.02

0.38 ± 0.03

0.32 ± 0.02

0.34 ± 0.02

0.34 ± 0.01

0.34 ± 0.006

 

160 - 180

0.31-0.44

0.30-0.41

0.26-0.39

0.24-0.39

0.20-0.27

0.23-0.28

0.23-0.28

0.24-0.26

0.26

 

0.39 ± 0.03

0.36 ± 0.02

0.32 ± 0.02

0.29 ± 0.03

0.24 ± 0.02

0.25 ± 0.01

0.25 ± 0.01

0.25 ± 0.004

 

180 - 200

0.23-0.36

0.20-0.33

0.18-0.31

0.18-0.34

0.13-0.21

0.16-0.20

0.15-0.20

0.16-0.18

0.19

 

0.29 ± 0.03

0.27 ± 0.02

0.24 ± 0.02

0.22 ± 0.04

0.17 ± 0.01

0.18 ± 0.1

0.17 ± 0.01

0.17 ± 0.004

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