Table 1 OR and bias from simulated cohorts under different control sampling designs based on 100 replicates for each design
| Â | Generated hazard ratio | ID sampling | CE sampling | |||||
|---|---|---|---|---|---|---|---|---|
SNP | OR | MAF | OR (CI)a | Bias ratio | Power | OR (CI) | Bias ratio | Power |
Gene1.3_0.1 | 1.3 | 0.1 | 1.29 (0.83-1.99) | 0.99 | 0.43 | 1.38 (0.86-2.18) | 1.06 | 0.66 |
Gene1.3_0.3 | 1.3 | 0.3 | 1.30 (0.79-1.26) | 1.00 | 0.97 | 1.37 (0.77-1.29) | 1.04 | 0.98 |
Gene1.3_0.5 | 1.3 | 0.5 | 1.29 (0.80-1.25) | 0.99 | 0.96 | 1.36 (0.78-1.29) | 1.04 | 0.99 |
Gene1.5_0.1 | 1.5 | 0.1 | 1.57 (0.49-2.05) | 1.04 | 0.92 | 1.59 (0.52-1.90) | 1.06 | 0.91 |
Gene1.5_0.3 | 1.5 | 0.3 | 1.54 (0.58-1.72) | 1.02 | 1.00 | 1.61 (0.59-1.71) | 1.08 | 1.00 |
Gene1.5_0.5 | 1.5 | 0.5 | 1.55 (0.55-1.82) | 1.03 | 1.00 | 1.62 (0.57-1.76) | 1.09 | 1.00 |
Gene1.8_0.1 | 1.8 | 0.1 | 1.90 (0.27-3.47) | 1.06 | 1.00 | 2.03 (0.24-4.18) | 1.13 | 1.00 |
Gene1.8_0.3 | 1.8 | 0.3 | 1.75 (0.38-2.64) | 0.97 | 1.00 | 1.96 (0.30-3.31) | 1.09 | 1.00 |
Gene1.8_0.5 | 1.8 | 0.5 | 1.77 (0.36-2.80) | 0.99 | 1.00 | 1.97 (0.29-3.47) | 1.09 | 1.00 |
Gene2_0.5 | 2.0 | 0.5 | 1.78 (0.52-2.08) | 0.89 | 1.00 | 2.64 (0.25-3.10) | 1.32 | 1.00 |
Gene3_0.5 | 3.0 | 0.5 | 2.92 (0.47-3.44) | 0.97 | 1.00 | 3.67 (0.38-4.34) | 1.22 | 1.00 |