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Table 2 OR for T2D SNPs from previous meta-analysis and in the FHS data under different control sampling designs

From: Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study

 

Previous studies

ID sampling

CE sampling

SNP

OR (CI)

MAF

OR (CI)a

OR (CI)

rs4607103

1.09 (1.06-1.12)

0.20

1.26 (0.56-2.83)

1.28 (0.71-2.35)

rs4747969

1.11 (1.07-1.14)

0.27

1.21 (0.53-2.74)

1.21 (0.63-2.29)

rs10946398

1.14 (1.11-1.17)

0.31

1.26 (0.85-1.86)

1.24 (0.73-2.09)

rs7754840

1.12 (1.08-1.16)

0.31

1.24 (0.84-1.85)

1.30 (0.75-2.27)

rs10811661

1.20 (1.14-1.25)

0.21

1.32 (0.66-2.63)

1.14 (0.57-2.28)

rs564398

1.12 (1.07-1.17)

0.37

0.91 (0.63-1.31)

1.21 (0.73-2.01)

rs8050136

1.17 (1.12-1.22)

0.45

1.05 (0.73-1.48)

1.69 (1.05-2.72)

rs9939609

1.11 (1.02-1.20)

0.45

1.16 (0.74-1.47)

1.69 (1.06-2.73)

rs5015480

1.15 (1.10-1.19)

0.43

1.25 (0.81-1.93)

1.21 (0.72-2.03)

rs4402960

1.14 (1.11-1.18)

0.29

1.01 (0.68-1.50)

1.02 (0.61-1.70)

rs864745

1.10 (1.07-1.13)

0.48

1.24 (0.80-1.91)

1.38 (0.83-2.29)

rs5215

1.14 (1.10-1.19)

0.41

1.14 (0.70-1.84)

1.03 (0.62-1.70)

rs1801282

1.14 (1.08-1.20)

0.07

1.02 (0.61-1.69)

1.01 (0.45-2.93)

rs10885409

1.29 (1.07-1.54)

0.42

1.25 (0.81-1.92)

1.50 (0.77-2.93)

rs7901695

1.37 (1.31-1.43)

0.28

1.34 (0.85-2.09)

1.07 (0.53-2.16)

rs13431070

1.15 (1.10-1.20)

0.08

1.33 (0.58-3.05)

1.02 (0.46-2.29)

rs7961581

1.09 (1.06-1.12)

0.23

1.16 (0.84-1.61)

1.03 (0.60-1.75)

rs4689394

1.11 (1.08-1.16)

0.27

1.18 (0.71-1.95)

1.23 (0.74-2.04)

  1. aAverage OR and CI (95% confidence interval) across 10 replicates
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