Skip to main content

Table 3 Association results for markers with p < 1.44 × 10-7

From: Genome-wide association analysis of cardiovascular-related quantitative traits in the Framingham Heart Study

     BMI time-invarianta BMI time-varyingb
Trait Locus Marker Minor allele (frequency) (SE)c p-Value (SE)c p-Value
LDL intercept 1p13 rs599839 G (0.23) -7.14 (1.19) 2.62 × 10-9 -7.33 (1.16) 3.04 × 10-10
TG slope 17q25 rs6501683 T (0.23) 4.73 (0.86) 3.89 × 10-8 5.25 (0.88) 2.98 × 10-9
  17q25 rs7213663 C (0.24) 4.26 (0.84) 4.98 × 10-7 4.68 (0.87) 7.47 × 10-8
  17q25 rs8074960 C (0.24) 4.31 (0.84) 3.27 × 10-7 4.71 (0.86) 5.51 × 10-8
  17q25 rs8075297 C (0.24) 4.17 (0.83) 5.30 × 10-7 4.57 (0.85) 8.99 × 10-8
SBP intercept 7p11 rs11976165 T (0.20) 2.53 (0.47) 6.88 × 10-8 2.11 (0.40) 1.45 × 10-7
  1. aPhenotypic model included sex, baseline age, diabetes status and baseline BMI as time-invariant covariates, and number of cigarettes smoked per day as a time-varying covariate.
  2. bPhenotypic model identical to BMI time-invariant model, except BMI was treated as a time-varying covariate.
  3. c represents the regression coefficient from the association analysis, and estimates the effect on the trait value by adding one copy of the minor allele; SE, standard error.