Table 3 Association results for markers with p < 1.44 × 10-7
BMI time-invarianta | BMI time-varyingb | ||||||
|---|---|---|---|---|---|---|---|
Trait | Locus | Marker | Minor allele (frequency) |
| p-Value |
| p-Value |
LDL intercept | 1p13 | rs599839 | G (0.23) | -7.14 (1.19) | 2.62 × 10-9 | -7.33 (1.16) | 3.04 × 10-10 |
TG slope | 17q25 | rs6501683 | T (0.23) | 4.73 (0.86) | 3.89 × 10-8 | 5.25 (0.88) | 2.98 × 10-9 |
17q25 | rs7213663 | C (0.24) | 4.26 (0.84) | 4.98 × 10-7 | 4.68 (0.87) | 7.47 × 10-8 | |
17q25 | rs8074960 | C (0.24) | 4.31 (0.84) | 3.27 × 10-7 | 4.71 (0.86) | 5.51 × 10-8 | |
17q25 | rs8075297 | C (0.24) | 4.17 (0.83) | 5.30 × 10-7 | 4.57 (0.85) | 8.99 × 10-8 | |
SBP intercept | 7p11 | rs11976165 | T (0.20) | 2.53 (0.47) | 6.88 × 10-8 | 2.11 (0.40) | 1.45 × 10-7 |
(SE)c- aPhenotypic model included sex, baseline age, diabetes status and baseline BMI as time-invariant covariates, and number of cigarettes smoked per day as a time-varying covariate.
- bPhenotypic model identical to BMI time-invariant model, except BMI was treated as a time-varying covariate.
- c
represents the regression coefficient from the association analysis, and estimates the effect on the trait value by adding one copy of the minor allele; SE, standard error.