Table 2 Mean χ2 statistics (μ-χ2) and type 1 error rates (at a nominal p) of QTDT, QTLD, and MG association tests
μ-χ2(SD) | p= 5% | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Trait | Gene | SNP | QTDT | QTLD | QTLD_S | MG | MG_S | QTDT | QTLD_S | MG_S |
A. No association and no linkage | ||||||||||
HDL | none | rs2521760 | 0.48 (0.62) | 0.82 (1.00) | 0.82 (1.00) | 0.73 (0.85) | 0.72 (0.86) | 0% | 1% | 0% |
TG | 0.86 (1.10) | 1.00 (1.15) | 0.97 (1.15) | 0.64 (0.70) | 0.60 (0.69) | 3% | 4% | 1% | ||
TG_Rob | 0.99 (1.28) | 0.92 (1.24) | 0.76 (1.03) | 0.48 (0.63) | 0.44 (0.62) | 4% | 4% | 0% | ||
B. No association and linkage | ||||||||||
HDL | LPL | rs17091651 | 1.03 (1.12) | 1.36 (1.51) | 1.36 (1.51) | 0.93 (1.01) | 0.93 (1.01) | 2% | 7% | 3% |
rs4244457 | 1.50 (1.79) | 1.03 (1.36) | 0.60 (0.92) | 0.63 (0.79) | 0.51 (0.75) | 6% | 1% | 1% | ||
CYP2B7P1/ | r11083567 | 0.85 (0.97) | 0.48 (0.63) | 0.38 (0.53) | 0.40 (0.51) | 0.37 (0.52) | 2% | 0% | 0% | |
CYP2B6 | rs1631931 | 1.86 (2.02) | 0.72 (1.09) | 0.61 (0.85) | 1.08 (1.24) | 0.99 (1.19) | 12% | 1% | 1% | |
TG | LPL | rs17091651 | 0.70 (0.88) | 0.93 (1.31) | 0.88 (1.32) | 0.89 (1.10) | 0.83 (1.12) | 1% | 4% | 5% |
rs4244457 | 1.76 (1.86) | 1.27 (1.46) | 0.99 (1.32) | 0.65 (1.13) | 0.61 (1.12) | 14% | 5% | 3% | ||
CYP2B6 | rs11083567 | 0.75 (0.95) | 1.11 (1.22) | 1.03 (1.18) | 0.55 (0.77) | 0.53 (0.77) | 1% | 3% | 2% | |
rs1631931 | 0.93 (1.35) | 1.19 (1.41) | 1.10 (1.33) | 0.62 (0.79) | 0.61 (0.79) | 6% | 7% | 1% | ||
TG_Rob | LPL | rs17091651 | 0.75 (0.99) | 0.89 (1.22) | 0.77 (1.16) | 0.80 (0.89) | 0.74 (0.89) | 2% | 3% | 1% |
rs4244457 | 1.52 (1.74) | 0.75 (1.20) | 0.66 (1.20) | 0.52 (0.98) | 0.49 (0.99) | 9% | 4% | 3% | ||
CYP2B6 | rs11083567 | 0.73 (1.03) | 0.66 (1.15) | 0.66 (1.16) | 0.5 (0.69) | 0.5 (0.69) | 2% | 1% | 0% | |
rs1631931 | 0.97 (1.29) | 0.85 (1.04) | 0.79 (0.98) | 0.75 (0.93) | 0.74 (0.93) | 2% | 2% | 1% | ||