Table 1 Significant pathways identified by three test statistic methods
From: Pathway-based analysis of a genome-wide case-control association study of rheumatoid arthritis
|  |  | χ 2 | DirEV | IndirEV | |||
|---|---|---|---|---|---|---|---|
Gene sets/pathways | No. genesa | Rankb | FDR q-value | Rank | FDR q-value | Rank | FDR q-value |
Hsa04612 antigen processing and presentation | 57 | 1 | <1*10-8 | 1 | <1*10-8 | 1 | <1*10-8 |
Hsa04940 Type I diabetes mellitus | 40 | 2 | <1*10-8 | 2 | <1*10-8 | 2 | <1*10-8 |
Wieland hepatitis B-induced | 87 | 3 | <1*10-8 | 3 | 0.004 | 3 | 0.001 |
Ctla4 pathway | 18 | 4 | 6*10-5 | 6 | 0.006 | 4 | 0.003 |
Ami pathway | 22 | 5 | 0.01 | 7 | 0.006 | 10 | 0.015 |
Csk pathway | 22 | 6 | 0.01 | 10 | 0.011 | 7 | 0.012 |
Sana Ifng endothelial up | 67 | 7 | 0.011 | 8 | 0.006 | 9 | 0.013 |
Th1th2 pathway | 17 | 8 | 0.011 | 9 | 0.009 | 8 | 0.013 |
Inflam pathway | 28 | 9 | 0.012 | 4 | 0.005 | 6 | 0.006 |
Hsa04514 cell adhesion molecule | 115 | 10 | 0.02 | 5 | 0.005 | 5 | 0.004 |