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Table 1 Strongest signals of rare variant association with RA (p < 10-4) outside of the MHCa

From: Identification of novel putative rheumatoid arthritis susceptibility genes via analysis of rare variants

  

Rare variants

  

Gene

Chromosome

Number

Mean MAF (%)

Odds ratio

(95% CI)

p-Value

FRY

13

5

2.6

0.10 (0.03-0.28)

1.4 × 10-5

PRPS1L1

7

1

4.4

0.46 (0.31-0.68)

7.3 × 10-5

ARNTL1

11

1

3.0

0.38 (0.24-0.61)

7.3 × 10-5

  1. aEach gene-based test has been adjusted for sex and five axes of genetic variation to account for population structure.
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BMC Proceedings

ISSN: 1753-6561

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