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Table 2 Strongest signals of rare variant association with RA (p < 10-4) outside of the MHC, adjusting for the effects of HLA-DRB1a

From: Identification of novel putative rheumatoid arthritis susceptibility genes via analysis of rare variants

  

Rare variants

  

Gene

Chromosome

Number

Mean MAF (%)

Odds ratio (95% CI)

p-value

TRIM58

1

3

1.1

0.04 (0.01-0.18)

3.7 × 10-5

HINT1

5

4

3.0

0.25 (0.13-0.48)

4.6 × 10-5

  1. aEach gene-based test has been adjusted for sex, five axes of genetic variation to account for population structure, and the number of shared epitope alleles to allow for the effects of HLA-DRB1.
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BMC Proceedings

ISSN: 1753-6561

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