BMC Proceedings

Table 5 Proportion of explained variability for the genetic factors contributing to CAC^a (by visit)

From: The Genetic Analysis Workshop 16 Problem 3: simulation of heritable longitudinal cardiovascular phenotypes based on actual genome-wide single-nucleotide polymorphisms in the Framingham Heart Study

		Factor		L1^b		L2
Factor	Visit	Mean	(Min - Max)	Mean	(Min - Max)	Mean	(Min - Max)
ME	1	0.0053	0.0037 - 0.0065	0.00002	0.0^c - 0.00012	0.00030	0.00008 - 0.00063
	2	0.0092	0.0075 - 0.0112	0.00003	0.0 - 0.00013	0.00055	0.00015 - 0.00093
	3	0.0115	0.0091 - 0.0137	0.00003	0.0 - 0.00019	0.00066	0.00027 - 0.00127
PE	1	0.0091	0.0076 - 0.0115	0.00004	0.0 - 0.00020	0.00003	0.0 - 0.00014
	2	0.0176	0.0152 - 0.0212	0.00004	0.0 - 0.00017	0.00004	0.0 - 0.00019
	3	0.0226	0.0191 - 0.0266	0.00004	0.0 - 0.00021	0.00004	0.0 - 0.00016
Het	1	0.0021	0.0012 - 0.0032
	2	0.0045	0.0032 - 0.0060
	3	0.0062	0.0045 - 0.0080

^aModels included the genetic factors age, sex, CHOL, and HDL.
^bColumns L1 and L2 indicate the effect of each of the epistatic loci when analyzed without its mate.
^c0.0 indicates R²<10^-5

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ISSN: 1753-6561

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