Table 1 SNPs showing TRD (TDT p < 10-5) with genotype clustering passing ACPA
From: Transmission-ratio distortion in the Framingham Heart Study
SNP | Chra | Nucleotide position in build 36 | Tb | Uc | ORd | TDT p-value | Minor:major allele | MAFe | HWE pf | MISSg | Mendel error count | Nearest gene(s) and location |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs12091564 | 1 | 144,106,961 | 103 | 178 | 0.58 | 7.7 × 10-6 | C:T | 0.06 | 0.70 | 0.010 | 0 | Intergenic NBPF8 and HFE2 |
rs17015803 | 2 | 119,907,901 | 58 | 124 | 0.47 | 1.0 × 10-6 | C:T | 0.04 | 0.13 | 0.014 | 1 | TMEM37 intron 1 |
rs1000548 | 2 | 233,900,041 | 107 | 218 | 0.49 | 7.4 × 10-10 | C:T | 0.07 | 0.09 | 0.011 | 3 | SAG intron 6 |
rs17684740 | 5 | 126,748,314 | 28 | 79 | 0.35 | 8.2 × 10-7 | C:T | 0.04 | 0.66 | 0.009 | 1 | MEGF10 intron 6 |
rs757128 | 5 | 136,648,485 | 27 | 76 | 0.36 | 1.4 × 10-6 | A:G | 0.03 | 0.42 | 0.016 | 0 | SPOCK1 intron 2 |
rs7029570 | 9 | 96,722,609 | 59 | 130 | 0.45 | 2.4 × 10-7 | G:A | 0.05 | 0.17 | 0.015 | 1 | C9orf3 intron 5 |
rs1156214 | 9 | 121,995,064 | 535 | 394 | 1.36 | 3.7 × 10-6 | G:T | 0.25 | 0.02 | 0.002 | 4 | DBC1, CDK5RAP2, MEGF9 |
rs3786228 | 18 | 75,565,158 | 500 | 663 | 0.75 | 1.8 × 10-6 | C:T | 0.37 | 0.09 | 0.002 | 0 | CTDP1 intron 4 |