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Table 1 LASSO results

From: Combining least absolute shrinkage and selection operator (LASSO) and principal-components analysis for detection of gene-gene interactions in genome-wide association studies

 

LASSO/PCA approach

LASSO/SNP approach

Gene × Gene

Lasso coef (SE)

CI

Lasso coef (SE)

CI

HLA-B × HLA-DQB1 a

-0.0446 (0.0600)

(-0.162, 0.073)

  

HLA-B × HLA-DRA

0.0452 (0.0781)

(-0.108, 0.198)

  

HLA-DMB × HLA-DQA2 b

-0.0044 (0.0435)

(-0.090, 0.081)

  

HLA-DPA1 × MICA

0.0197 (0.0261)

(-0.031, 0.071)

  

HLA-DPB1 × MICA a, b

0.1047 (0.0601)

(-0.013, 0.223)

  

HLA-DQA2 × TNFRSF21

-0.0356 (0.0230)

(-0.081, 0.010)

  

HLA-DQB1 × TNF

-0.1848 (0.1073)

(-0.395, 0.026)

  

HLA-DRA × HLA-DRB9 a, b

0.2334 (0.0817)

(0.073, 0.394)c

-0.3574 (0.0872)

(-0.528, -0.186)c

HLA-DRA × MICA a, b

-0.1125 (0.0528)

(-0.216, -0.009)c

-0.2665 (0.0826)

(-0.428, -0.104)c

HLA-DRA × TNF

0.1214 (0.0933)

(-0.062, 0.304)

  

HLA-DRA × TNFRSF21

-0.0252 (0.0232)

(-0.071, 0.020)

-0.0078 (0.0465)

(-0.099, 0.083)

HLA-F × MICD

-0.0042 (0.0435)

(-0.089, 0.081)

  

MICA × MICB a, b

-0.0307 (0.0330)

(-0.095, 0.034)

  

MICA × TNF

0.0280 (0.0514)

(-0.073, 0.129)

  

MICA × TNFAIP3

-0.0179 (0.0230)

(-0.063, 0.027)

  

TAP2 × TNF

0.0202 (0.0354)

(-0.049, 0.090)

  

HLA-DPB1 × TAP2 a

  

0.0372 (0.0812)

(-0.122, 0.196)

HLA-DQB1 × HLA-DRA a

  

-0.0068 (0.0433)

(-0.092, 0.078)

HLA-DQB1 × MICD

  

-0.0316 (0.0417)

(-0.113, 0.050)

HLA-DRA × TAP2 a

  

-0.0715 (0.0565)

(-0.182, 0.039)

MICA × TAP2 a

  

-0.0482 (0.0434)

(-0.133, 0.037)

MICB × MICD a

  

0.0478 (0.0539)

(-0.058, 0.153)

MICB × TAP2 a

  

0.0933 (0.0768)

(-0.057, 0.244)

MICD × TAP2

  

0.1257 (0.0933)

(-0.057, 0.309)

  1. aLogistic model with significant SNPgene_a-SNPgene_binteractions
  2. bLogistic model with significant PCAgene_a-PCAgene_binteractions
  3. cSignificant finding; gene_a is the ath gene and gene_b the bth gene where a ≠ b