A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis

BMC Proceedings

Table 3 {SNP₁;SNP₂;C} interaction with KWII values ≥ 95^th percentile of the two variable KWII obtained for Data Set 1 and consisting of SNPs only in 6p21.3 (and not in any candidate gene), for Data Set 2, and for Data Set 3)

SNP1-SNP2	Gene/genome region 1 - Gene/genome region 2	KWII	p-Value^b
Data Set 1: = 0.07^a
rs2647050-rs2858332	6p21.3-6p21.3	0.144	0
rs9357152-rs2858332	6p21.3-6p21.3	0.098	0
rs9275141-rs2858331	6p21.3-6p21.3	0.092	0
rs7774434-rs2856718	6p21.3-6p21.3	0.08	0
rs9275371-rs7765379	6p21.3-6p21.3	0.076	3.35 × 10^-14
rs660895-rs7755224	6p21.3-6p21.3	0.073	1.73 × 10^-7
rs9357152-rs9275555	6p21.3-6p21.3	0.07	9.98 × 10^-8
Data Set 2: = 0.02
rs9263871-rs9263969	MICA-MICA	0.03	1.35 × 10^-8
rs11967684-rs2523608	MICA-MICA	0.025	2.22 × 10^-14
rs9263871-rs2596501	MICA-MICA	0.022	1.81 × 10^-5
rs11967684-rs7755852	MICA-MICA	0.02	2.45 × 10^-8
rs3873380-rs7755852	MICA-MICA	0.02	1.39 × 10^-9
Data Set 3: = 0.01
rs1542876-rs1513737	RUNX1-RUNX1	0.015	1.85 × 10^-6

^a denotes the 95^th percentile KWII for combinations of order i and Data Set j.
^b p-Value obtained using logistic regression.

ISSN: 1753-6561