Table 1 Statistical power (%) for haplotype-based and mixed model analyses of the Covariate-adjusted LDL measurement in 200 replicates
Mixed modelb | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Haplotype-baseda | rs4648068 × SNP | Marginal effect | ||||||||
rs4648068 × SNPc | Genotype analysis | Additive genotype recoding | Genotype analysis | Additive genotype recoding | ||||||
SNP | α = 5% | 1% | 5% | 1% | 5% | 1% | 5% | 1% | 5% | 1% |
rs4648068 | - | - | - | - | 13 e | 2.57 | 44.5 | 16.9 | ||
rs263 | 1 | 0 | 2.5 | 0 | 21.5 | 4.5 | 11 | 1 | 88 | 58.5 |
rs271 | 3 | 0 | 37 | 15.5 | 2.5 | 0 | 21 | 5 | 45.5 | 18 |
rs11570892 | 0.5 | 0 | 2 | 0 | 1.5 | 0 | 17 | 2 | 60 | 27 |
rs3200218 | 17 | 3.5 | 5 | 0 | 3.5 | 0 | 95.5 | 80.5 | 86.5 | 57 |
rs2410616 | 0.5 | 0 | 0.5 | 0 | 3 | 0 | 14 | 3 | 72 | 37.5 |
rs2898493 | 4.5 | 1 | 9 | 1.5 | 1 | 0 | 3.5 | 0 | 0.5 | 0 |
rs17482753 | 1 | 0 | 20 | 5 | 32.5 | 7 | 2 | 0 | 63 | 25.5 |
Overalld | 3.9 | 0.6 | 10.9 | 3.14 | 9.36 | 1.64 | 18.2 | 7.82 | 51.9 | 24.4 |