Incorporating biological knowledge in the search for gene × gene interaction in genome-wide association studies

BMC Proceedings

Table 1 Top ten pair-wise interaction results among SNPs with main-effects p-values < 1 × 10^-4 from logistic regression models

SNP 1	Chr	Position (1,000 bp)	Closest gene	SNP 2	Chr	Position (1,000 bp)	Closest gene	Interaction p-value
rs1333914	9	121623	DBC1	rs9391858^a	6	32449	C6orf10	5.7 × 10^-5
rs9368950	6	36736	CDKN1A	rs9408926	9	122955	CEP110	5.7 × 10^-5
rs3873444	6	32791	HLA-DQA2	rs17172185	7	43253	HECW1	1.1 × 10^-4
rs9368950	6	36736	CDKN1A	rs9408928	9	122992	RAB14	1.9 × 10^-4
rs7679231	4	137102	PCDH18	rs8017455	14	80645	TSHR	2.4 × 10^-4
rs532098	6	32686	HLA-DRB1	rs660895^a	6	32685	HLA-DRB1	2.6 × 10^-4
rs4674520	2	201422	CLK1	rs2524123^a	6	31373	HLA-C	3.3 × 10^-4
rs10948693	6	52262	MCM3	rs7330752	13	29755	KATNAL1	3.8 × 10^-4
rs4674520	2	201427	CLK1	rs10948693	6	52262	MCM3	4.0 × 10^-4

ISSN: 1753-6561