Table 1 Genome-wide association of SNPs with RA in NARAC sample, best SNP on each chromosome
From: Effects of covariates and interactions on a genome-wide association analysis of rheumatoid arthritis
Chr | SNP | Position | Minor allele/major allele | Association p-value | Allelic OR (95% CI) | Bonferroni adjusted p-value | BH-false discovery rate p-value | Interaction (ADD × sex) p-value |
|---|---|---|---|---|---|---|---|---|
1 | rs865682 | 223,080,777 | A/G | 4.545 × 10-6 | 0.39(0.26-0.60) | 0.16 | 0.16 | - |
2 | rs12477038 | 201,518,282 | G/A | 1.038 × 10-5 | 0.47(0.33-0.66) | 0.41 | 0.25 | 0.09 |
3 | rs6775137 | 193,649,851 | A/C | 2.124 × 10-5 | 0.65(0.53-0.79) | 0.70 | 0.70 | - |
4 | rs512244 | 12,775,151 | G/A | 8.362 × 10-8 | 2.2(1.7-3.0) | 0.002 | 0.002 | 0.14 |
5 | rs7726943 | 67,854,337 | G/A | 2.991 × 10-6 | 0.62(0.50-0.76) | 0.09 | 0.09 | 0.21 |
6 | rs660895 | 32,685,358 | G/A | 8.346 × 10-24 | 3.4(2.7-4.3) | 2.642 × 10-19 | 2.642 × 10-19 | 5.263 × 10-45 |
7 | rs17470799 | 100,768,534 | A/G | 6.937 × 10-6 | 0.4(0.27-0.60) | 0.18 | 0.12 | 1.0 |
8 | rs966561 | 6,642,801 | A/G | 6.817 × 10-5 | 0.68(0.56-0.82) | 1.0 | 0.54 | 0.93 |
9 | rs306772 | 121,171,909 | A/G | 3.559 × 10-5 | 1.7(1.3-2.1) | 0.83 | 0.40 | 0.09 |
10 | rs7072006 | 133,595,618 | A/G | 5.309 × 10-6 | 0.48(0.35-0.67) | 0.13 | 0.13 | 0.78 |
11 | rs761453 | 31,834,576 | A/G | 3.867 × 10-5 | 0.61(0.48-0.77) | 0.91 | 0.46 | 0.52 |
12 | rs2283275 | 2,054,821 | G/A | 4.362 × 10-6 | 0.59(0.47-0.74) | 0.10 | 0.10 | 0.98 |
13 | rs17086849 | 28,064,399 | A/G | 3.158 × 10-6 | 0.56(0.44-0.72) | 0.06 | 0.06 | 0.94 |
14 | rs12885166 | 92,195,035 | A/C | 1.139 × 10-5 | 1.6(1.3-1.9) | 0.18 | 0.18 | 0.45 |
15 | rs11857639 | 71,424,825 | A/G | 1.083 × 10-5 | 0.39(0.25-0.61) | 0.16 | 0.16 | 1.0 |
16 | rs1076251 | 73,326,313 | A/C | 6.524 × 10-6 | 0.59(0.46-0.74) | 0.10 | 0.10 | 0.21 |
17 | rs1039519 | 3,394,664 | G/A | 7.11 × 10-5 | 1.52(1.2-1.9) | 0.90 | 0.60 | - |
18 | rs2174899 | 72,420,808 | G/A | 3.671 × 10-5 | 0.57(0.44-0.75) | 0.54 | 0.54 | - |
19 | rs9630874 | 57,619,851 | A/C | 1.27 × 10-5 | 0.31(0.17-0.54) | 0.10 | 0.10 | 0.51 |
20 | rs1182531 | 57,826,397 | A/C | 4.314-6 | 0.56(0.43-0.71) | 0.05 | 0.05 | 0.17 |
21 | rs12626622 | 31,981,460 | A/G | 2.063 × 10-4 | 1.8(1.3-2.4) | 1.0 | 0.52 | 0.20 |
22 | rs3830104 | 35,033,124 | G/A | 3.974 × 10-5 | 2.3(1.5-3.5) | 0.29 | 0.21 | 0.73 |