Integration of a priori gene set information into genome-wide association studies

BMC Proceedings

Table 1 Top gene sets after applying GSEA, one/two-step HPB, or HBP+GSEA

rank	Strategy I: GSEA	Strategy II: HBP	Strategy III: HBP+HBP	Strategy IV: HBP+GSEA
1	hsa04514 ^a	hsa04330 ^a	GO0032393 ^a	hsa04940 ^b
2	hsa04640	GO0032395^b	GO0002504 ^b	hsa04514 ^a
3	hsa04612 ^c	GO0006956 ^a	GO0048002 ^b	GO0008236
4	hsa04940 ^b	GO0016820	GO0051327	hsa04612 ^c
5	inflamPathway	GO0051028	asbcellPathway ^b	GO0032395^b
6	th1th2Pathway ^a	GO0004004	GO0042287	GO0002504 ^b
7	CSKPathway	GO0030554	GO0032395^b	GO0048002 ^b
8	ctla4Pathway^b	GO0000279	GO0001569	GO0051249 ^a
9	blymphoPathway	GO0051276	GO0051249	hsa04512 ^a
10	hsa04650 ^a	GO0019199	GO0002526 ^b	GO0032393 ^a
11	tcraPathway	GO0002460 ^c	GO0006957	th1th2Pathway ^a
12	GO0048002 ^b	GO0007160	GO0002460 ^c	hsa04650 ^a
13	GO0046982	hsa04940 ^b	ctla4Pathway ^b	hsa04610
14	GO0009405	hsa04612 ^c	hsa00310	GO0002526 ^b
15	asbcellPathway ^b	hsa04010	hsa04512^a	GO0002460 ^c
16	hsa04330 ^a	GO0043069	GO00051169	ctla4Path ^b
17	GO0006956 ^a	GO0002521	hsa04612 ^c	GO0002443 ^a
18	GO0002504 ^b	GO0002443 ^a	hsa04320	GO0004175
19	GO0002460 ^c	GO0006281	GO0006643	asbcellPathway ^b
20	GO0002526 ^b	GO0009952	GO0016301	GO0003779

ISSN: 1753-6561